ATXN2L [The Human Chemical-Genetic Interaction Map Project]

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======= ATXN2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATXN2L
  * **<color #00a2e8>Official Name</color>**: ataxin 2 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11273|11273]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WWM7|Q8WWM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ATXN2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ATXN2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607931|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LsmAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cytoplasmic mRNA processing body assembly|
|stress granule assembly|
|cytoplasmic stress granule|
|regulation of organelle assembly|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|cadherin binding|
|nuclear speck|
|regulation of protein complex assembly|
|ribonucleoprotein complex biogenesis|
|organelle assembly|
|cellular protein-containing complex assembly|
|regulation of cellular component biogenesis|
|regulation of organelle organization|
|RNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.58|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.5|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.39|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.02|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.92|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.9|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.86|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.83|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.72|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.71|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.74|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.81|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.86|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.89|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.9|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.93|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.07|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.11|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.23|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.24|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.37|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.47|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.65|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.86|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|4.1|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|5.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lsm12|LSM12]]|0.665|
|[[:human genes:c:cdk6|CDK6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ATXN2L Expression in NALM6 Cells: 8.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>