B4GALT1 [The Human Chemical-Genetic Interaction Map Project]

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======= B4GALT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: B4GALT1
  * **<color #00a2e8>Official Name</color>**: beta-1,4-galactosyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2683|2683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15291|P15291]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=B4GALT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20B4GALT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Galactosyl T 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-galactosyltransferase activity|
|lactose synthase activity|
|lactose metabolic process|
|lactose biosynthetic process|
|beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|
|N-acetyllactosamine synthase activity|
|disaccharide biosynthetic process|
|development of secondary sexual characteristics|
|penetration of zona pellucida|
|positive regulation of epithelial cell proliferation involved in wound healing|
|Golgi trans cisterna|
|disaccharide metabolic process|
|galactose metabolic process|
|angiogenesis involved in wound healing|
|oligosaccharide biosynthetic process|
|galactosyltransferase activity|
|regulation of acrosome reaction|
|desmosome|
|regulation of fertilization|
|keratan sulfate biosynthetic process|
|keratan sulfate metabolic process|
|binding of sperm to zona pellucida|
|oligosaccharide metabolic process|
|sperm-egg recognition|
|brush border membrane|
|azurophil granule membrane|
|cellular carbohydrate biosynthetic process|
|manganese ion binding|
|acute inflammatory response|
|cell-cell recognition|
|filopodium|
|protein N-linked glycosylation|
|Golgi cisterna membrane|
|secretory granule membrane|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|carbohydrate biosynthetic process|
|single fertilization|
|glycosaminoglycan metabolic process|
|hexose metabolic process|
|regulation of reproductive process|
|aminoglycan metabolic process|
|cellular carbohydrate metabolic process|
|fertilization|
|sulfur compound biosynthetic process|
|positive regulation of epithelial cell proliferation|
|epithelial cell development|
|basolateral plasma membrane|
|monosaccharide metabolic process|
|multi-multicellular organism process|
|cell recognition|
|macromolecule glycosylation|
|protein glycosylation|
|glycosylation|
|angiogenesis|
|glycoprotein biosynthetic process|
|regulation of epithelial cell proliferation|
|protein homooligomerization|
|extracellular matrix organization|
|sulfur compound metabolic process|
|leukocyte migration|
|extracellular structure organization|
|glycoprotein metabolic process|
|external side of plasma membrane|
|blood vessel morphogenesis|
|carbohydrate metabolic process|
|wound healing|
|blood vessel development|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|vasculature development|
|leukocyte degranulation|
|cardiovascular system development|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|response to wounding|
|myeloid leukocyte activation|
|carbohydrate derivative biosynthetic process|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|positive regulation of cell death|
|regulated exocytosis|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|Golgi apparatus|
|multi-organism reproductive process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|epithelium development|
|secretion|
|locomotion|
|defense response|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|cell development|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='B4GALT1 Expression in NALM6 Cells: 8.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>