BACE1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BACE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BACE1
  * **<color #00a2e8>Official Name</color>**: beta-secretase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23621|23621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56817|P56817]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BACE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BACE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604252|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Asp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi-associated vesicle lumen|
|beta-aspartyl-peptidase activity|
|cellular response to manganese ion|
|detection of mechanical stimulus involved in sensory perception of pain|
|prepulse inhibition|
|response to manganese ion|
|amyloid-beta metabolic process|
|aspartic-type endopeptidase activity|
|membrane protein ectodomain proteolysis|
|response to lead ion|
|startle response|
|detection of mechanical stimulus involved in sensory perception|
|cellular response to copper ion|
|multivesicular body|
|hippocampal mossy fiber to CA3 synapse|
|membrane protein proteolysis|
|cellular response to amyloid-beta|
|detection of mechanical stimulus|
|response to copper ion|
|response to amyloid-beta|
|positive regulation of neuron apoptotic process|
|sensory perception of pain|
|endopeptidase activity|
|regulation of synaptic vesicle exocytosis|
|peptidase activity|
|amyloid-beta binding|
|positive regulation of neuron death|
|regulation of neurotransmitter secretion|
|neuromuscular process|
|regulation of synaptic vesicle cycle|
|recycling endosome|
|synaptic vesicle|
|detection of external stimulus|
|detection of abiotic stimulus|
|late endosome|
|cytoplasmic vesicle membrane|
|regulation of neurotransmitter transport|
|regulation of regulated secretory pathway|
|sensory perception of mechanical stimulus|
|trans-Golgi network|
|cellular response to metal ion|
|regulation of neuron apoptotic process|
|response to mechanical stimulus|
|endosome membrane|
|cellular response to inorganic substance|
|regulation of exocytosis|
|membrane raft|
|lysosome|
|early endosome|
|endosome|
|axon|
|endoplasmic reticulum lumen|
|regulation of neuron death|
|cellular response to peptide|
|enzyme binding|
|regulation of neurotransmitter levels|
|negative regulation of response to external stimulus|
|response to metal ion|
|neuronal cell body|
|dendrite|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to peptide|
|peptide metabolic process|
|response to inorganic substance|
|detection of stimulus involved in sensory perception|
|regulation of vesicle-mediated transport|
|cellular response to organonitrogen compound|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|protein catabolic process|
|detection of stimulus|
|positive regulation of cell death|
|regulation of secretion by cell|
|cellular amide metabolic process|
|regulation of secretion|
|regulation of cellular localization|
|sensory perception|
|Golgi apparatus|
|response to organonitrogen compound|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|proteolysis|
|nervous system process|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|organic substance catabolic process|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14691
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BACE1 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>