BACH2 [The Human Chemical-Genetic Interaction Map Project]

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======= BACH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BACH2
  * **<color #00a2e8>Official Name</color>**: BTB domain and CNC homolog 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60468|60468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYV9|Q9BYV9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BACH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BACH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605394|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). {ECO:0000250|UniProtKB:P97303, ECO:0000269|PubMed:17018862}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
|bZIP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|import into nucleus|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|nucleocytoplasmic transport|
|nuclear transport|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-3.34|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-3.18|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.9|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.86|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.75|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.64|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.47|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.29|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.28|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.27|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.26|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.2|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.18|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.17|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.16|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.11|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-2.02|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.99|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.98|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.97|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.97|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.94|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.92|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.91|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.87|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.83|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.78|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.75|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.7|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.87|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.96|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.01|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.26|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.41|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.6|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.77|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:keap1|KEAP1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4397
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BACH2 Expression in NALM6 Cells: 8.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>