BAG3 [The Human Chemical-Genetic Interaction Map Project]

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======= BAG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BAG3
  * **<color #00a2e8>Official Name</color>**: BAG cochaperone 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9531|9531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95817|O95817]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BAG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BAG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603883|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). {ECO:0000269|PubMed:10597216, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:26159920, ECO:0000269|PubMed:27474739, ECO:0000269|PubMed:9873016}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|BAG|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of aggrephagy|
|regulation of aggrephagy|
|aggresome assembly|
|negative regulation of protein targeting to mitochondrion|
|inclusion body assembly|
|chaperone-mediated autophagy|
|negative regulation of establishment of protein localization to mitochondrion|
|adenyl-nucleotide exchange factor activity|
|chaperone complex|
|chaperone-mediated protein transport|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|muscle cell cellular homeostasis|
|positive regulation of protein export from nucleus|
|negative regulation of striated muscle cell apoptotic process|
|dynein intermediate chain binding|
|extrinsic apoptotic signaling pathway in absence of ligand|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of protein import into nucleus|
|negative regulation of muscle cell apoptotic process|
|regulation of protein export from nucleus|
|regulation of striated muscle cell apoptotic process|
|positive regulation of protein import|
|negative regulation of intracellular protein transport|
|aggresome|
|regulation of protein targeting to mitochondrion|
|negative regulation of mitochondrion organization|
|regulation of protein import into nucleus|
|regulation of protein import|
|negative regulation of intracellular transport|
|autophagosome assembly|
|positive regulation of nucleocytoplasmic transport|
|autophagosome organization|
|positive regulation of macroautophagy|
|microtubule-based protein transport|
|protein transport along microtubule|
|stress fiber|
|regulation of muscle cell apoptotic process|
|cellular response to heat|
|regulation of establishment of protein localization to mitochondrion|
|positive regulation of protein localization to nucleus|
|cellular response to mechanical stimulus|
|regulation of cellular response to heat|
|regulation of protein targeting|
|extrinsic apoptotic signaling pathway|
|chaperone binding|
|regulation of nucleocytoplasmic transport|
|spinal cord development|
|response to heat|
|negative regulation of cellular protein localization|
|regulation of protein localization to nucleus|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|positive regulation of autophagy|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|vacuole organization|
|Z disc|
|cellular response to topologically incorrect protein|
|positive regulation of intracellular protein transport|
|transport along microtubule|
|macroautophagy|
|response to unfolded protein|
|regulation of macroautophagy|
|cytoskeleton-dependent intracellular transport|
|response to temperature stimulus|
|protein stabilization|
|regulation of mitochondrion organization|
|negative regulation of protein transport|
|microtubule-based transport|
|negative regulation of establishment of protein localization|
|response to topologically incorrect protein|
|positive regulation of intracellular transport|
|response to mechanical stimulus|
|protein folding|
|regulation of intracellular protein transport|
|autophagy|
|process utilizing autophagic mechanism|
|protein-containing complex binding|
|microtubule-based movement|
|apoptotic signaling pathway|
|regulation of protein stability|
|cadherin binding|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|neuron projection|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|cellular response to external stimulus|
|anatomical structure homeostasis|
|regulation of intracellular transport|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|positive regulation of establishment of protein localization|
|negative regulation of transport|
|regulation of cellular protein localization|
|microtubule-based process|
|protein catabolic process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|organelle assembly|
|head development|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|central nervous system development|
|positive regulation of transport|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13121
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BAG3 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>