BATF [The Human Chemical-Genetic Interaction Map Project]

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======= BATF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BATF
  * **<color #00a2e8>Official Name</color>**: basic leucine zipper ATF-like transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10538|10538]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16520|Q16520]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BATF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BATF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612476|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune- specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|T-helper 2 cell differentiation|
|T-helper 17 cell lineage commitment|
|T-helper 17 type immune response|
|type 2 immune response|
|T-helper 17 cell differentiation|
|T-helper cell lineage commitment|
|CD4-positive, alpha-beta T cell lineage commitment|
|lymphoid progenitor cell differentiation|
|hematopoietic stem cell differentiation|
|alpha-beta T cell lineage commitment|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|myeloid dendritic cell differentiation|
|somatic diversification of immunoglobulins involved in immune response|
|somatic recombination of immunoglobulin genes involved in immune response|
|isotype switching|
|T cell lineage commitment|
|myeloid dendritic cell activation|
|defense response to protozoan|
|somatic recombination of immunoglobulin gene segments|
|response to protozoan|
|positive T cell selection|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|T-helper cell differentiation|
|alpha-beta T cell activation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|dendritic cell differentiation|
|T cell differentiation involved in immune response|
|CD4-positive, alpha-beta T cell differentiation|
|somatic diversification of immune receptors via germline recombination within a single locus|
|somatic cell DNA recombination|
|somatic diversification of immunoglobulins|
|CD4-positive, alpha-beta T cell activation|
|T cell selection|
|B cell activation involved in immune response|
|somatic diversification of immune receptors|
|alpha-beta T cell differentiation|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|DNA damage response, signal transduction by p53 class mediator|
|hematopoietic progenitor cell differentiation|
|signal transduction in response to DNA damage|
|lymphocyte activation involved in immune response|
|myeloid leukocyte differentiation|
|signal transduction by p53 class mediator|
|T cell differentiation|
|cytokine production|
|B cell activation|
|immunoglobulin production|
|stem cell differentiation|
|production of molecular mediator of immune response|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|myeloid cell differentiation|
|DNA recombination|
|T cell activation|
|lymphocyte differentiation|
|cell fate commitment|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|leukocyte differentiation|
|lymphocyte activation|
|sequence-specific DNA binding|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|DNA metabolic process|
|leukocyte mediated immunity|
|cellular response to DNA damage stimulus|
|leukocyte activation|
|defense response to other organism|
|cellular response to cytokine stimulus|
|cell activation|
|immune effector process|
|response to cytokine|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.551|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15015
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BATF Expression in NALM6 Cells: -0.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>