BCAR1 [The Human Chemical-Genetic Interaction Map Project]

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======= BCAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCAR1
  * **<color #00a2e8>Official Name</color>**: BCAR1 scaffold protein, Cas family member
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9564|9564]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56945|P56945]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|DUF3513|
|Serine rich|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament reorganization|
|hepatocyte growth factor receptor signaling pathway|
|cellular response to hepatocyte growth factor stimulus|
|response to hepatocyte growth factor|
|neurotrophin TRK receptor signaling pathway|
|neurotrophin signaling pathway|
|platelet-derived growth factor receptor signaling pathway|
|epidermal growth factor receptor signaling pathway|
|actin cytoskeleton reorganization|
|vascular endothelial growth factor receptor signaling pathway|
|ERBB signaling pathway|
|insulin receptor signaling pathway|
|ruffle|
|integrin-mediated signaling pathway|
|positive regulation of endothelial cell migration|
|B cell receptor signaling pathway|
|SH3 domain binding|
|positive regulation of epithelial cell migration|
|regulation of endothelial cell migration|
|cellular response to insulin stimulus|
|T cell receptor signaling pathway|
|lamellipodium|
|cell chemotaxis|
|actin cytoskeleton|
|regulation of epithelial cell migration|
|response to insulin|
|actin filament organization|
|cellular response to peptide hormone stimulus|
|antigen receptor-mediated signaling pathway|
|cellular response to peptide|
|response to peptide hormone|
|focal adhesion|
|regulation of cell growth|
|immune response-activating cell surface receptor signaling pathway|
|supramolecular fiber organization|
|protein kinase binding|
|response to peptide|
|immune response-regulating cell surface receptor signaling pathway|
|cell division|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|activation of immune response|
|cellular response to nitrogen compound|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|regulation of cell migration|
|positive regulation of immune response|
|response to hormone|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|cellular response to endogenous stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to endogenous stimulus|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 120/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|1/28|
|bone|2/26|
|breast|5/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|5/21|
|liver|4/20|
|lung|12/75|
|lymphocyte|0/16|
|ovary|6/26|
|pancreas|12/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12130
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCAR1 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>