BCOR [The Human Chemical-Genetic Interaction Map Project]

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======= BCOR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCOR
  * **<color #00a2e8>Official Name</color>**: BCL6 corepressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54880|54880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6W2J9|Q6W2J9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCOR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCOR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300485|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BCOR complex|
|negative regulation of histone H3-K36 methylation|
|negative regulation of tooth mineralization|
|specification of axis polarity|
|negative regulation of odontogenesis|
|negative regulation of histone H3-K4 methylation|
|regulation of histone H3-K36 methylation|
|regulation of tooth mineralization|
|histone H2A monoubiquitination|
|negative regulation of bone mineralization|
|negative regulation of histone methylation|
|histone H2A ubiquitination|
|hatching|
|organism emergence from protective structure|
|blastocyst hatching|
|regulation of odontogenesis|
|regulation of histone H3-K4 methylation|
|negative regulation of biomineral tissue development|
|negative regulation of biomineralization|
|histone monoubiquitination|
|negative regulation of animal organ morphogenesis|
|histone ubiquitination|
|negative regulation of histone modification|
|heat shock protein binding|
|negative regulation of chromatin organization|
|protein monoubiquitination|
|regulation of histone methylation|
|negative regulation of ossification|
|regulation of bone mineralization|
|axis specification|
|roof of mouth development|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|blastocyst development|
|histone deacetylase binding|
|odontogenesis|
|negative regulation of chromosome organization|
|regulation of histone modification|
|regulation of chromatin organization|
|regulation of ossification|
|transcription regulatory region DNA binding|
|transcription corepressor activity|
|ubiquitin-protein transferase activity|
|regulation of animal organ morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|transcription factor binding|
|regulation of chromosome organization|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|in utero embryonic development|
|pattern specification process|
|heart development|
|negative regulation of protein modification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein ubiquitination|
|chromatin organization|
|negative regulation of cellular component organization|
|protein modification by small protein conjugation|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|protein modification by small protein conjugation or removal|
|negative regulation of cellular protein metabolic process|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|negative regulation of protein metabolic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.75|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.69|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.68|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.5|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.5|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.36|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.3|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.28|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.26|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.21|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.19|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.17|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-2.15|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.13|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.13|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.11|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.07|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.06|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.06|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.99|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.99|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.98|
|[[:results:exp539|42°C R08 exp539]]|-1.96|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.95|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.92|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.89|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.86|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.83|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.73|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.73|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.71|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.71|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.71|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.8|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.81|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.81|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.82|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.87|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.01|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.12|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.23|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.43|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pcgf1|PCGF1]]|0.675|
|[[:human genes:r:ring1|RING1]]|0.543|
|[[:human genes:p:pou2af1|POU2AF1]]|0.521|
|[[:human genes:u:ube2e1|UBE2E1]]|0.518|
|[[:human genes:p:polr2j3|POLR2J3]]|0.485|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.479|
|[[:human genes:t:tcf3|TCF3]]|0.466|
|[[:human genes:i:ikzf2|IKZF2]]|0.439|
|[[:human genes:g:glyr1|GLYR1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|1/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2415
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCOR Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>