BCR [The Human Chemical-Genetic Interaction Map Project]

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======= BCR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCR
  * **<color #00a2e8>Official Name</color>**: BCR activator of RhoGEF and GTPase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=613|613]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11274|P11274]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity. {ECO:0000269|PubMed:1657398, ECO:0000269|PubMed:1903516}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bcr-Abl Oligo|
|RhoGAP|
|PH|
|C2|
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of neutrophil degranulation|
|negative regulation of blood vessel remodeling|
|negative regulation of neutrophil activation|
|negative regulation of respiratory burst|
|regulation of neutrophil degranulation|
|regulation of blood vessel remodeling|
|negative regulation of cellular extravasation|
|regulation of neutrophil activation|
|negative regulation of myeloid leukocyte mediated immunity|
|negative regulation of leukocyte degranulation|
|regulation of respiratory burst|
|definitive hemopoiesis|
|postsynaptic density, intracellular component|
|negative regulation of tissue remodeling|
|negative regulation of regulated secretory pathway|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|regulation of cellular extravasation|
|platelet-derived growth factor receptor signaling pathway|
|negative regulation of exocytosis|
|adherens junction assembly|
|regulation of vascular permeability|
|cell-substrate junction assembly|
|negative regulation of leukocyte migration|
|negative regulation of leukocyte mediated immunity|
|regulation of leukocyte degranulation|
|intracellular protein transmembrane transport|
|neuromuscular process controlling balance|
|negative regulation of reactive oxygen species metabolic process|
|regulation of myeloid leukocyte mediated immunity|
|protein transmembrane transport|
|positive regulation of phagocytosis|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of tissue remodeling|
|kinase activity|
|Schaffer collateral - CA1 synapse|
|adherens junction organization|
|regulation of phagocytosis|
|activation of GTPase activity|
|inner ear morphogenesis|
|guanyl-nucleotide exchange factor activity|
|neuromuscular process|
|renal system process|
|ear morphogenesis|
|negative regulation of immune effector process|
|cell-matrix adhesion|
|negative regulation of inflammatory response|
|regulation of Rho protein signal transduction|
|negative regulation of immune response|
|regulation of regulated secretory pathway|
|cell junction assembly|
|vascular process in circulatory system|
|negative regulation of leukocyte activation|
|regulation of reactive oxygen species metabolic process|
|cellular response to lipopolysaccharide|
|cell-substrate adhesion|
|cellular response to molecule of bacterial origin|
|protein autophosphorylation|
|inner ear development|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|postsynaptic membrane|
|homeostasis of number of cells|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|cell junction organization|
|cellular response to biotic stimulus|
|ear development|
|regulation of exocytosis|
|negative regulation of secretion|
|regulation of Ras protein signal transduction|
|postsynaptic density|
|sensory organ morphogenesis|
|negative regulation of cell migration|
|negative regulation of cell motility|
|keratinocyte differentiation|
|GTPase activator activity|
|embryonic organ morphogenesis|
|negative regulation of cellular component movement|
|response to lipopolysaccharide|
|epidermal cell differentiation|
|small GTPase mediated signal transduction|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|regulation of small GTPase mediated signal transduction|
|glutamatergic synapse|
|protein serine/threonine kinase activity|
|negative regulation of response to external stimulus|
|skin development|
|blood circulation|
|circulatory system process|
|positive regulation of GTPase activity|
|epidermis development|
|embryonic organ development|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of immune effector process|
|regulation of GTPase activity|
|negative regulation of transport|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cellular response to lipid|
|sensory organ development|
|cell junction|
|regulation of vesicle-mediated transport|
|hemopoiesis|
|embryonic morphogenesis|
|actin filament-based process|
|protein-containing complex|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|epithelial cell differentiation|
|response to bacterium|
|enzyme linked receptor protein signaling pathway|
|brain development|
|regulation of secretion by cell|
|regulation of defense response|
|positive regulation of hydrolase activity|
|head development|
|regulation of secretion|
|regulation of cell migration|
|response to lipid|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|intracellular protein transport|
|regulation of cellular component movement|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|cytoskeleton organization|
|epithelium development|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|transmembrane transport|
|regulation of hydrolase activity|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of response to stress|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|5/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9312
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCR Expression in NALM6 Cells: 8.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>