BCS1L [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BCS1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BCS1L
  * **<color #00a2e8>Official Name</color>**: BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=617|617]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y276|Q9Y276]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BCS1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BCS1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603647|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. {ECO:0000269|PubMed:18628306}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|BCS1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory chain complex III assembly|
|mitochondrial respiratory chain complex III assembly|
|mitochondrial respiratory chain complex III|
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|ATP binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.72|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.79|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.85|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.85|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.87|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.88|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.88|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.89|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.95|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.01|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.02|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.26|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.3|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.3|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.38|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dars2|DARS2]]|0.712|
|[[:human genes:s:sco2|SCO2]]|0.71|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.706|
|[[:human genes:y:yars2|YARS2]]|0.697|
|[[:human genes:s:selrc1|SELRC1]]|0.692|
|[[:human genes:g:gfm1|GFM1]]|0.677|
|[[:human genes:m:mrpl21|MRPL21]]|0.674|
|[[:human genes:c:cox16|COX16]]|0.665|
|[[:human genes:n:nars2|NARS2]]|0.643|
|[[:human genes:t:tars2|TARS2]]|0.642|
|[[:human genes:m:mrps14|MRPS14]]|0.639|
|[[:human genes:s:sars2|SARS2]]|0.637|
|[[:human genes:d:dap3|DAP3]]|0.631|
|[[:human genes:m:mrps5|MRPS5]]|0.629|
|[[:human genes:s:slc25a26|SLC25A26]]|0.623|
|[[:human genes:v:vars2|VARS2]]|0.621|
|[[:human genes:r:rpusd4|RPUSD4]]|0.619|
|[[:human genes:m:mrps6|MRPS6]]|0.617|
|[[:human genes:m:mrps26|MRPS26]]|0.616|
|[[:human genes:m:mrps34|MRPS34]]|0.615|
|[[:human genes:c:cox7b|COX7B]]|0.615|
|[[:human genes:e:ears2|EARS2]]|0.612|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.61|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.607|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.607|
|[[:human genes:q:qrsl1|QRSL1]]|0.607|
|[[:human genes:m:mrp63|MRP63]]|0.604|
|[[:human genes:f:fastkd5|FASTKD5]]|0.603|
|[[:human genes:p:pars2|PARS2]]|0.599|
|[[:human genes:t:tufm|TUFM]]|0.598|
|[[:human genes:g:gfm2|GFM2]]|0.597|
|[[:human genes:m:mrps16|MRPS16]]|0.595|
|[[:human genes:m:mrpl47|MRPL47]]|0.595|
|[[:human genes:m:mrpl23|MRPL23]]|0.588|
|[[:human genes:w:wbscr16|WBSCR16]]|0.588|
|[[:human genes:a:atp5d|ATP5D]]|0.587|
|[[:human genes:m:mrpl53|MRPL53]]|0.583|
|[[:human genes:m:mrps21|MRPS21]]|0.58|
|[[:human genes:r:rbfa|RBFA]]|0.579|
|[[:human genes:p:pnpt1|PNPT1]]|0.577|
|[[:human genes:m:mtpap|MTPAP]]|0.575|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.574|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.573|
|[[:human genes:t:tmem242|TMEM242]]|0.572|
|[[:human genes:n:ndufb11|NDUFB11]]|0.571|
|[[:human genes:u:uqcr10|UQCR10]]|0.57|
|[[:human genes:f:fars2|FARS2]]|0.57|
|[[:human genes:c:coa3|COA3]]|0.569|
|[[:human genes:a:atp5a1|ATP5A1]]|0.568|
|[[:human genes:c:c10orf2|C10orf2]]|0.567|
|[[:human genes:l:lars2|LARS2]]|0.563|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.562|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.56|
|[[:human genes:c:cox11|COX11]]|0.56|
|[[:human genes:a:atp5b|ATP5B]]|0.56|
|[[:human genes:d:dhrsx|DHRSX]]|0.559|
|[[:human genes:f:fh|FH]]|0.557|
|[[:human genes:c:cox15|COX15]]|0.556|
|[[:human genes:c:c17orf89|C17orf89]]|0.555|
|[[:human genes:h:hars2|HARS2]]|0.553|
|[[:human genes:m:mrps2|MRPS2]]|0.552|
|[[:human genes:r:rars2|RARS2]]|0.552|
|[[:human genes:g:gatc|GATC]]|0.55|
|[[:human genes:n:ndufa3|NDUFA3]]|0.545|
|[[:human genes:p:pgm3|PGM3]]|0.542|
|[[:human genes:a:atp5o|ATP5O]]|0.54|
|[[:human genes:c:c12orf65|C12orf65]]|0.54|
|[[:human genes:m:mrps9|MRPS9]]|0.539|
|[[:human genes:m:mrpl20|MRPL20]]|0.536|
|[[:human genes:t:tefm|TEFM]]|0.535|
|[[:human genes:l:lsm10|LSM10]]|0.535|
|[[:human genes:m:mars2|MARS2]]|0.535|
|[[:human genes:a:atp5c1|ATP5C1]]|0.534|
|[[:human genes:c:cox6c|COX6C]]|0.533|
|[[:human genes:n:ndufb5|NDUFB5]]|0.531|
|[[:human genes:m:mtg2|MTG2]]|0.531|
|[[:human genes:c:cox17|COX17]]|0.528|
|[[:human genes:m:mrpl15|MRPL15]]|0.526|
|[[:human genes:m:mrps23|MRPS23]]|0.525|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.524|
|[[:human genes:p:pdss1|PDSS1]]|0.522|
|[[:human genes:t:thg1l|THG1L]]|0.521|
|[[:human genes:t:triap1|TRIAP1]]|0.52|
|[[:human genes:m:mrps18a|MRPS18A]]|0.519|
|[[:human genes:c:coa6|COA6]]|0.516|
|[[:human genes:f:ftsj2|FTSJ2]]|0.516|
|[[:human genes:a:atic|ATIC]]|0.516|
|[[:human genes:a:atp5j|ATP5J]]|0.515|
|[[:human genes:m:mrps24|MRPS24]]|0.514|
|[[:human genes:m:mrps25|MRPS25]]|0.513|
|[[:human genes:p:polg|POLG]]|0.509|
|[[:human genes:c:chchd4|CHCHD4]]|0.508|
|[[:human genes:a:atxn10|ATXN10]]|0.507|
|[[:human genes:p:polg2|POLG2]]|0.504|
|[[:human genes:m:mrpl12|MRPL12]]|0.503|
|[[:human genes:a:aars2|AARS2]]|0.501|
|[[:human genes:d:dohh|DOHH]]|0.499|
|[[:human genes:r:rpe|RPE]]|0.499|
|[[:human genes:c:coq2|COQ2]]|0.498|
|[[:human genes:m:mrps33|MRPS33]]|0.497|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.495|
|[[:human genes:n:ndufb3|NDUFB3]]|0.495|
|[[:human genes:m:mrpl45|MRPL45]]|0.494|
|[[:human genes:s:slc25a19|SLC25A19]]|0.494|
|[[:human genes:p:pet117|PET117]]|0.493|
|[[:human genes:u:uap1|UAP1]]|0.489|
|[[:human genes:n:ndufa1|NDUFA1]]|0.488|
|[[:human genes:m:mrpl44|MRPL44]]|0.488|
|[[:human genes:a:atp5e|ATP5E]]|0.488|
|[[:human genes:m:mrps12|MRPS12]]|0.487|
|[[:human genes:u:uqcc2|UQCC2]]|0.487|
|[[:human genes:h:hccs|HCCS]]|0.486|
|[[:human genes:d:dnlz|DNLZ]]|0.486|
|[[:human genes:m:mrps11|MRPS11]]|0.486|
|[[:human genes:m:mtg1|MTG1]]|0.484|
|[[:human genes:r:rpia|RPIA]]|0.482|
|[[:human genes:c:c11orf57|C11orf57]]|0.48|
|[[:human genes:t:tpk1|TPK1]]|0.478|
|[[:human genes:a:atp5f1|ATP5F1]]|0.478|
|[[:human genes:v:vezt|VEZT]]|0.477|
|[[:human genes:d:dpagt1|DPAGT1]]|0.477|
|[[:human genes:u:urm1|URM1]]|0.477|
|[[:human genes:n:ndufa2|NDUFA2]]|0.476|
|[[:human genes:p:pet100|PET100]]|0.476|
|[[:human genes:m:mettl17|METTL17]]|0.475|
|[[:human genes:w:wars2|WARS2]]|0.474|
|[[:human genes:n:ndufc2|NDUFC2]]|0.473|
|[[:human genes:u:uqcrq|UQCRQ]]|0.472|
|[[:human genes:c:coq7|COQ7]]|0.471|
|[[:human genes:e:elac2|ELAC2]]|0.47|
|[[:human genes:m:mrpl55|MRPL55]]|0.47|
|[[:human genes:m:mrpl18|MRPL18]]|0.469|
|[[:human genes:m:mrps10|MRPS10]]|0.468|
|[[:human genes:t:tfam|TFAM]]|0.467|
|[[:human genes:s:srp14|SRP14]]|0.466|
|[[:human genes:d:dhx30|DHX30]]|0.466|
|[[:human genes:p:pmm2|PMM2]]|0.465|
|[[:human genes:t:trmt61a|TRMT61A]]|0.465|
|[[:human genes:p:ppa2|PPA2]]|0.464|
|[[:human genes:t:tmem126b|TMEM126B]]|0.464|
|[[:human genes:m:mrpl27|MRPL27]]|0.464|
|[[:human genes:c:coa5|COA5]]|0.463|
|[[:human genes:n:ndufs7|NDUFS7]]|0.462|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.459|
|[[:human genes:a:alg6|ALG6]]|0.459|
|[[:human genes:a:atp5h|ATP5H]]|0.459|
|[[:human genes:n:ndufs2|NDUFS2]]|0.458|
|[[:human genes:p:ppcs|PPCS]]|0.458|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.458|
|[[:human genes:a:atp5l|ATP5L]]|0.457|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.457|
|[[:human genes:s:ssb|SSB]]|0.456|
|[[:human genes:k:kdsr|KDSR]]|0.456|
|[[:human genes:n:ndufv1|NDUFV1]]|0.455|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.455|
|[[:human genes:s:sdha|SDHA]]|0.453|
|[[:human genes:p:polrmt|POLRMT]]|0.452|
|[[:human genes:t:trub2|TRUB2]]|0.452|
|[[:human genes:p:pet112|PET112]]|0.451|
|[[:human genes:t:tomm20|TOMM20]]|0.45|
|[[:human genes:a:alg13|ALG13]]|0.45|
|[[:human genes:c:cox5a|COX5A]]|0.449|
|[[:human genes:m:mtif3|MTIF3]]|0.448|
|[[:human genes:n:ndufb9|NDUFB9]]|0.446|
|[[:human genes:m:mrpl11|MRPL11]]|0.446|
|[[:human genes:c:coq4|COQ4]]|0.445|
|[[:human genes:n:nfu1|NFU1]]|0.443|
|[[:human genes:t:tkt|TKT]]|0.443|
|[[:human genes:a:alas1|ALAS1]]|0.442|
|[[:human genes:s:slc25a3|SLC25A3]]|0.441|
|[[:human genes:m:mrpl34|MRPL34]]|0.44|
|[[:human genes:m:mrpl36|MRPL36]]|0.44|
|[[:human genes:h:higd2a|HIGD2A]]|0.439|
|[[:human genes:t:tomm40|TOMM40]]|0.438|
|[[:human genes:c:cycs|CYCS]]|0.437|
|[[:human genes:m:mrpl42|MRPL42]]|0.436|
|[[:human genes:d:dolk|DOLK]]|0.435|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.435|
|[[:human genes:m:mrpl39|MRPL39]]|0.434|
|[[:human genes:t:ten1|TEN1]]|0.434|
|[[:human genes:p:ptdss1|PTDSS1]]|0.434|
|[[:human genes:c:cars2|CARS2]]|0.432|
|[[:human genes:m:mterfd1|MTERFD1]]|0.432|
|[[:human genes:u:ube2g2|UBE2G2]]|0.432|
|[[:human genes:m:mrpl3|MRPL3]]|0.432|
|[[:human genes:m:mipep|MIPEP]]|0.431|
|[[:human genes:f:fastkd1|FASTKD1]]|0.43|
|[[:human genes:g:gemin7|GEMIN7]]|0.43|
|[[:human genes:c:coq3|COQ3]]|0.43|
|[[:human genes:r:rbmx2|RBMX2]]|0.429|
|[[:human genes:e:eif3f|EIF3F]]|0.429|
|[[:human genes:s:slc25a52|SLC25A52]]|0.428|
|[[:human genes:r:romo1|ROMO1]]|0.428|
|[[:human genes:n:ndufb1|NDUFB1]]|0.428|
|[[:human genes:c:cox6b1|COX6B1]]|0.427|
|[[:human genes:n:ndufb6|NDUFB6]]|0.427|
|[[:human genes:m:mterfd2|MTERFD2]]|0.426|
|[[:human genes:m:mrpl43|MRPL43]]|0.426|
|[[:human genes:i:iba57|IBA57]]|0.423|
|[[:human genes:m:mrpl33|MRPL33]]|0.422|
|[[:human genes:e:exoc4|EXOC4]]|0.422|
|[[:human genes:c:coq5|COQ5]]|0.422|
|[[:human genes:s:sec62|SEC62]]|0.421|
|[[:human genes:c:cept1|CEPT1]]|0.421|
|[[:human genes:g:gfpt1|GFPT1]]|0.421|
|[[:human genes:c:crls1|CRLS1]]|0.421|
|[[:human genes:o:opa1|OPA1]]|0.421|
|[[:human genes:s:srd5a3|SRD5A3]]|0.42|
|[[:human genes:r:rpusd3|RPUSD3]]|0.42|
|[[:human genes:e:ecsit|ECSIT]]|0.419|
|[[:human genes:a:aifm1|AIFM1]]|0.417|
|[[:human genes:z:zcrb1|ZCRB1]]|0.415|
|[[:human genes:t:trmt10a|TRMT10A]]|0.415|
|[[:human genes:m:mrpl38|MRPL38]]|0.414|
|[[:human genes:t:timm8b|TIMM8B]]|0.413|
|[[:human genes:m:mocs3|MOCS3]]|0.412|
|[[:human genes:t:trnt1|TRNT1]]|0.412|
|[[:human genes:a:atp5sl|ATP5SL]]|0.412|
|[[:human genes:t:tamm41|TAMM41]]|0.411|
|[[:human genes:m:mrpl22|MRPL22]]|0.411|
|[[:human genes:g:gmppb|GMPPB]]|0.41|
|[[:human genes:m:mrps22|MRPS22]]|0.41|
|[[:human genes:t:tomm6|TOMM6]]|0.41|
|[[:human genes:m:msto1|MSTO1]]|0.41|
|[[:human genes:m:mrpl4|MRPL4]]|0.409|
|[[:human genes:p:pgs1|PGS1]]|0.409|
|[[:human genes:c:cox20|COX20]]|0.408|
|[[:human genes:a:adsl|ADSL]]|0.408|
|[[:human genes:a:alg8|ALG8]]|0.408|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.407|
|[[:human genes:p:pmvk|PMVK]]|0.407|
|[[:human genes:n:ndufs5|NDUFS5]]|0.406|
|[[:human genes:n:n6amt1|N6AMT1]]|0.405|
|[[:human genes:p:ppp6c|PPP6C]]|0.404|
|[[:human genes:c:coq6|COQ6]]|0.404|
|[[:human genes:t:taz|TAZ]]|0.403|
|[[:human genes:t:txnl4b|TXNL4B]]|0.403|
|[[:human genes:u:uhrf1|UHRF1]]|0.402|
|[[:human genes:p:pdcd5|PDCD5]]|0.401|
|[[:human genes:u:uba5|UBA5]]|0.401|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.4|
|[[:human genes:r:rpp21|RPP21]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|1/26|
|breast|3/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|3/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 670
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BCS1L Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>