BGN [The Human Chemical-Genetic Interaction Map Project]

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======= BGN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BGN
  * **<color #00a2e8>Official Name</color>**: biglycan
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=633|633]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21810|P21810]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BGN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BGN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301870|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in collagen fiber assembly. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRRNT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|
|dermatan sulfate biosynthetic process|
|dermatan sulfate metabolic process|
|chondroitin sulfate catabolic process|
|dermatan sulfate proteoglycan biosynthetic process|
|extracellular matrix structural constituent conferring compression resistance|
|dermatan sulfate proteoglycan metabolic process|
|glycosaminoglycan binding|
|chondroitin sulfate biosynthetic process|
|extracellular matrix binding|
|chondroitin sulfate proteoglycan biosynthetic process|
|blood vessel remodeling|
|chondroitin sulfate metabolic process|
|chondroitin sulfate proteoglycan metabolic process|
|sulfur compound catabolic process|
|peptide cross-linking|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|proteoglycan biosynthetic process|
|transport vesicle|
|proteoglycan metabolic process|
|lysosomal lumen|
|sarcolemma|
|tissue remodeling|
|Golgi lumen|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|extracellular matrix structural constituent|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|sulfur compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|carbohydrate derivative catabolic process|
|peptidyl-serine modification|
|extracellular matrix|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycoprotein biosynthetic process|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|sulfur compound metabolic process|
|extracellular structure organization|
|glycoprotein metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|cell surface|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BGN Expression in NALM6 Cells: 0.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>