BIK [The Human Chemical-Genetic Interaction Map Project]

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======= BIK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIK
  * **<color #00a2e8>Official Name</color>**: BCL2 interacting killer
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=638|638]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13323|Q13323]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603392|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269|PubMed:8521816}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bcl-2I13|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein homooligomerization|
|regulation of protein homooligomerization|
|positive regulation of protein oligomerization|
|positive regulation of release of cytochrome c from mitochondria|
|regulation of protein oligomerization|
|regulation of release of cytochrome c from mitochondria|
|apoptotic mitochondrial changes|
|endomembrane system|
|mitochondrial membrane|
|positive regulation of mitochondrion organization|
|male gonad development|
|development of primary male sexual characteristics|
|male sex differentiation|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|gonad development|
|development of primary sexual characteristics|
|positive regulation of protein complex assembly|
|sex differentiation|
|regulation of apoptotic signaling pathway|
|reproductive structure development|
|reproductive system development|
|mitochondrion organization|
|regulation of protein complex assembly|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|positive regulation of cell death|
|apoptotic process|
|regulation of cellular component biogenesis|
|programmed cell death|
|cell death|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.93|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.74|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.81|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.85|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.86|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.91|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.21|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|2.31|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:bcl2l11|BCL2L11]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7542
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIK Expression in NALM6 Cells: 3.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>