BIRC5 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BIRC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIRC5
  * **<color #00a2e8>Official Name</color>**: baculoviral IAP repeat containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=332|332]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15392|O15392]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIRC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIRC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603352|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromosome passenger complex|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|nuclear chromosome|
|Ran GTPase binding|
|mitotic spindle assembly|
|spindle microtubule|
|chromosome, centromeric region|
|mitotic spindle organization|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|condensed chromosome kinetochore|
|negative regulation of cysteine-type endopeptidase activity|
|spindle assembly|
|chaperone binding|
|microtubule cytoskeleton organization involved in mitosis|
|sensory perception of sound|
|mitotic nuclear division|
|spindle organization|
|midbody|
|sensory perception of mechanical stimulus|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|microtubule binding|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|protein-containing complex localization|
|chromosome segregation|
|nuclear division|
|organelle fission|
|enzyme binding|
|negative regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|microtubule cytoskeleton organization|
|cell division|
|mitotic cell cycle process|
|microtubule-based process|
|cytokine-mediated signaling pathway|
|mitotic cell cycle|
|regulation of proteolysis|
|organelle assembly|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|sensory perception|
|protein phosphorylation|
|negative regulation of cell death|
|cell cycle process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of RNA metabolic process|
|cell cycle|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|negative regulation of gene expression|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.41|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.39|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.24|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.21|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.04|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.02|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.84|
|[[:results:exp539|42°C R08 exp539]]|-1.83|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.82|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.81|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.76|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.74|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.73|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.72|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.72|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.8|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|2.1|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|2.11|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.14|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 736/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 691
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIRC5 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>