BIRC8 [The Human Chemical-Genetic Interaction Map Project]

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======= BIRC8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BIRC8
  * **<color #00a2e8>Official Name</color>**: baculoviral IAP repeat containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112401|112401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96P09|Q96P09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BIRC8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BIRC8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protects against apoptosis mediated by BAX.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inhibition of cysteine-type endopeptidase activity involved in apoptotic process|
|zymogen inhibition|
|inhibition of cysteine-type endopeptidase activity|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|regulation of protein processing|
|regulation of protein maturation|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|regulation of protein ubiquitination|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|regulation of canonical Wnt signaling pathway|
|negative regulation of proteolysis|
|regulation of Wnt signaling pathway|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|protein ubiquitination|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.74|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.8|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BIRC8 Expression in NALM6 Cells: -2.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>