BMPR2 [The Human Chemical-Genetic Interaction Map Project]

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======= BMPR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BMPR2
  * **<color #00a2e8>Official Name</color>**: bone morphogenetic protein receptor type 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=659|659]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13873|Q13873]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BMPR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BMPR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600799|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. {ECO:0000250|UniProtKB:O35607}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|Activin recp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activin receptor activity, type II|
|negative regulation of cell proliferation involved in heart valve morphogenesis|
|negative regulation of cell proliferation involved in heart morphogenesis|
|negative regulation of chondrocyte proliferation|
|regulation of cell proliferation involved in heart valve morphogenesis|
|regulation of lung blood pressure|
|tricuspid valve morphogenesis|
|transforming growth factor beta receptor activity, type II|
|tricuspid valve development|
|spanning component of plasma membrane|
|negative regulation of vasoconstriction|
|positive regulation of axon extension involved in axon guidance|
|BMP receptor activity|
|pharyngeal arch artery morphogenesis|
|endothelial cell apoptotic process|
|positive regulation of axon guidance|
|lymphatic endothelial cell differentiation|
|mitral valve morphogenesis|
|BMP binding|
|mitral valve development|
|lymphangiogenesis|
|lymph vessel morphogenesis|
|venous blood vessel development|
|transforming growth factor beta-activated receptor activity|
|atrial septum morphogenesis|
|regulation of cell proliferation involved in heart morphogenesis|
|retina vasculature development in camera-type eye|
|negative regulation of systemic arterial blood pressure|
|atrial septum development|
|pulmonary valve development|
|lymph vessel development|
|endothelial cell proliferation|
|atrioventricular valve morphogenesis|
|activin receptor signaling pathway|
|pharyngeal system development|
|protein tyrosine kinase binding|
|atrioventricular valve development|
|epithelial cell apoptotic process|
|outflow tract septum morphogenesis|
|cardiac atrium morphogenesis|
|aortic valve development|
|growth factor binding|
|blood vessel remodeling|
|regulation of axon extension involved in axon guidance|
|positive regulation of BMP signaling pathway|
|positive regulation of cartilage development|
|negative regulation of blood circulation|
|negative regulation of animal organ morphogenesis|
|basal plasma membrane|
|maternal placenta development|
|cardiac atrium development|
|semi-lunar valve development|
|positive regulation of bone mineralization|
|negative regulation of DNA biosynthetic process|
|regulation of heart morphogenesis|
|lung alveolus development|
|ventricular septum morphogenesis|
|endocardial cushion development|
|chondrocyte development|
|positive regulation of axon extension|
|regulation of axon guidance|
|negative regulation of blood pressure|
|positive regulation of biomineral tissue development|
|positive regulation of biomineralization|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|heart valve morphogenesis|
|SMAD binding|
|positive regulation of blood vessel diameter|
|regulation of vasoconstriction|
|positive regulation of osteoblast differentiation|
|heart valve development|
|artery morphogenesis|
|regulation of pathway-restricted SMAD protein phosphorylation|
|maternal process involved in female pregnancy|
|mesoderm formation|
|proteoglycan biosynthetic process|
|mesoderm morphogenesis|
|regulation of cartilage development|
|ventricular septum development|
|endochondral bone morphogenesis|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|regulation of bone mineralization|
|caveola|
|endothelial cell differentiation|
|chondrocyte differentiation|
|positive regulation of ossification|
|artery development|
|positive regulation of axonogenesis|
|epithelial cell proliferation|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|proteoglycan metabolic process|
|positive regulation of endothelial cell proliferation|
|regulation of systemic arterial blood pressure|
|endothelium development|
|regulation of axon extension|
|positive regulation of endothelial cell migration|
|tissue remodeling|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell-cell adherens junction|
|cellular response to BMP stimulus|
|response to BMP|
|cardiac septum development|
|regulation of extent of cell growth|
|formation of primary germ layer|
|regulation of DNA biosynthetic process|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|negative regulation of DNA metabolic process|
|mesoderm development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|retina development in camera-type eye|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|cellular response to starvation|
|placenta development|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to transforming growth factor beta stimulus|
|regulation of endothelial cell migration|
|gastrulation|
|cardiac muscle tissue development|
|response to transforming growth factor beta|
|positive regulation of cell growth|
|lung development|
|vascular process in circulatory system|
|cardiac chamber development|
|positive regulation of developmental growth|
|cartilage development|
|respiratory tube development|
|female pregnancy|
|limb development|
|appendage development|
|regulation of cell size|
|regulation of blood pressure|
|negative regulation of cell growth|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|response to starvation|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|receptor complex|
|multi-multicellular organism process|
|regulation of chemotaxis|
|anterior/posterior pattern specification|
|regulation of epithelial cell migration|
|mesenchyme development|
|connective tissue development|
|cellular response to nutrient levels|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|negative regulation of growth|
|heart morphogenesis|
|postsynaptic density|
|regulation of animal organ morphogenesis|
|positive regulation of growth|
|cellular response to extracellular stimulus|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle tissue development|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|camera-type eye development|
|apical plasma membrane|
|glycoprotein biosynthetic process|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|regulation of DNA metabolic process|
|eye development|
|visual system development|
|sensory system development|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|glycoprotein metabolic process|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|regulation of cell growth|
|dendrite|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|positive regulation of neurogenesis|
|transcription by RNA polymerase II|
|blood vessel development|
|regulation of cell morphogenesis|
|skeletal system development|
|regulation of neuron projection development|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|sensory organ development|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of system process|
|positive regulation of response to external stimulus|
|cell surface|
|carbohydrate derivative biosynthetic process|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|carbohydrate derivative metabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell death|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.466|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12563
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BMPR2 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>