BNIP3 [The Human Chemical-Genetic Interaction Map Project]

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======= BNIP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BNIP3
  * **<color #00a2e8>Official Name</color>**: BCL2 interacting protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=664|664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12983|Q12983]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BNIP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BNIP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603293|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BNIP3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intrinsic apoptotic signaling pathway in response to hypoxia|
|negative regulation of mitochondrial membrane permeability involved in apoptotic process|
|cellular response to cobalt ion|
|cardiac muscle cell apoptotic process|
|striated muscle cell apoptotic process|
|mitochondrial protein catabolic process|
|granzyme-mediated apoptotic signaling pathway|
|negative regulation of mitochondrial fusion|
|muscle cell apoptotic process|
|negative regulation of mitochondrial membrane permeability|
|autophagic cell death|
|positive regulation of necrotic cell death|
|negative regulation of membrane permeability|
|regulation of aerobic respiration|
|regulation of mitochondrial fusion|
|response to cobalt ion|
|mitochondrial fragmentation involved in apoptotic process|
|positive regulation of mitochondrial calcium ion concentration|
|negative regulation of mitochondrial membrane potential|
|negative regulation of membrane potential|
|positive regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell apoptotic process|
|mitochondrial outer membrane permeabilization|
|positive regulation of mitochondrial fission|
|positive regulation of mitochondrial membrane permeability involved in apoptotic process|
|mitochondrial outer membrane permeabilization involved in programmed cell death|
|positive regulation of autophagy of mitochondrion|
|integral component of mitochondrial outer membrane|
|positive regulation of mitochondrial membrane permeability|
|response to hyperoxia|
|regulation of mitochondrial fission|
|regulation of mitochondrial membrane permeability involved in apoptotic process|
|positive regulation of membrane permeability|
|mitochondrial calcium ion homeostasis|
|positive regulation of muscle cell apoptotic process|
|brown fat cell differentiation|
|response to increased oxygen levels|
|regulation of necrotic cell death|
|positive regulation of release of cytochrome c from mitochondria|
|regulation of cellular respiration|
|GTPase binding|
|regulation of cardiac muscle cell apoptotic process|
|positive regulation of protein complex disassembly|
|mitochondrion disassembly|
|regulation of striated muscle cell apoptotic process|
|autophagy of mitochondrion|
|toxin transport|
|regulation of autophagy of mitochondrion|
|neuron apoptotic process|
|regulation of release of cytochrome c from mitochondria|
|neuron death|
|negative regulation of mitochondrion organization|
|negative regulation of reactive oxygen species metabolic process|
|apoptotic mitochondrial changes|
|organelle disassembly|
|positive regulation of macroautophagy|
|regulation of muscle cell apoptotic process|
|oligodendrocyte differentiation|
|cellular response to hydrogen peroxide|
|regulation of mitochondrial membrane potential|
|regulation of mitochondrial membrane permeability|
|cellular response to mechanical stimulus|
|regulation of membrane permeability|
|mitochondrial membrane|
|fat cell differentiation|
|reactive oxygen species metabolic process|
|regulation of protein complex disassembly|
|positive regulation of mitochondrion organization|
|cerebral cortex development|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|positive regulation of autophagy|
|mitochondrial membrane organization|
|cellular response to reactive oxygen species|
|intrinsic apoptotic signaling pathway|
|regulation of generation of precursor metabolites and energy|
|mitochondrial outer membrane|
|glial cell differentiation|
|regulation of macroautophagy|
|pallium development|
|positive regulation of apoptotic signaling pathway|
|regulation of reactive oxygen species metabolic process|
|nuclear envelope|
|regulation of mitochondrion organization|
|cellular response to hypoxia|
|cellular response to metal ion|
|defense response to virus|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|response to mechanical stimulus|
|cellular response to toxic substance|
|gliogenesis|
|cellular response to oxygen levels|
|mitochondrial transport|
|cellular response to inorganic substance|
|cellular response to oxidative stress|
|postsynaptic density|
|telencephalon development|
|autophagy|
|process utilizing autophagic mechanism|
|response to virus|
|apoptotic signaling pathway|
|response to antibiotic|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of autophagy|
|cellular response to external stimulus|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of cellular catabolic process|
|response to metal ion|
|negative regulation of organelle organization|
|response to oxygen levels|
|forebrain development|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|cellular component disassembly|
|cellular response to drug|
|dendrite|
|regulation of membrane potential|
|positive regulation of catabolic process|
|cellular calcium ion homeostasis|
|mitochondrion organization|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|protein heterodimerization activity|
|divalent inorganic cation homeostasis|
|response to toxic substance|
|response to inorganic substance|
|cellular metal ion homeostasis|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|protein catabolic process|
|response to bacterium|
|positive regulation of cell death|
|viral process|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of developmental process|
|defense response to other organism|
|central nervous system development|
|negative regulation of cell death|
|regulation of catabolic process|
|endoplasmic reticulum|
|response to drug|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|immune effector process|
|cell death|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3408
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BNIP3 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>