BRD8 [The Human Chemical-Genetic Interaction Map Project]

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======= BRD8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRD8
  * **<color #00a2e8>Official Name</color>**: bromodomain containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10902|10902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0E9|Q9H0E9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRD8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRD8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602848|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:10517671, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:24463511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromodomain|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Swr1 complex|
|histone H2A acetylation|
|NuA4 histone acetyltransferase complex|
|nuclear receptor activity|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|intracellular receptor signaling pathway|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|regulation of growth|
|DNA-binding transcription factor activity|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.25|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.15|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.15|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.11|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.04|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-1.92|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.72|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.71|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.84|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.9|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lig1|LIG1]]|0.414|
|[[:human genes:k:kpnb1|KPNB1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRD8 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>