BRIX1 [The Human Chemical-Genetic Interaction Map Project]

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======= BRIX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BRIX1
  * **<color #00a2e8>Official Name</color>**: biogenesis of ribosomes BRX1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55299|55299]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDN6|Q8TDN6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BRIX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BRIX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618466|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for biogenesis of the 60S ribosomal subunit.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Brix|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribosomal large subunit assembly|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.02|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.98|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.8|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.84|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.85|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.87|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.03|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.09|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.484|
|[[:human genes:p:psma7|PSMA7]]|0.468|
|[[:human genes:p:psmd14|PSMD14]]|0.463|
|[[:human genes:t:tsr1|TSR1]]|0.456|
|[[:human genes:r:rpl35|RPL35]]|0.452|
|[[:human genes:p:psma6|PSMA6]]|0.45|
|[[:human genes:k:kctd17|KCTD17]]|0.447|
|[[:human genes:b:bysl|BYSL]]|0.445|
|[[:human genes:p:psmb4|PSMB4]]|0.442|
|[[:human genes:n:nol10|NOL10]]|0.442|
|[[:human genes:r:rps7|RPS7]]|0.439|
|[[:human genes:r:rpl6|RPL6]]|0.437|
|[[:human genes:r:rpl38|RPL38]]|0.436|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.433|
|[[:human genes:w:wdr46|WDR46]]|0.426|
|[[:human genes:r:rpl34|RPL34]]|0.425|
|[[:human genes:t:twistnb|TWISTNB]]|0.422|
|[[:human genes:w:wdr75|WDR75]]|0.416|
|[[:human genes:p:psmb2|PSMB2]]|0.416|
|[[:human genes:p:polr2f|POLR2F]]|0.416|
|[[:human genes:p:psmd11|PSMD11]]|0.414|
|[[:human genes:c:chd4|CHD4]]|0.413|
|[[:human genes:r:rps12|RPS12]]|0.412|
|[[:human genes:d:ddtl|DDTL]]|0.412|
|[[:human genes:z:znf219|ZNF219]]|0.409|
|[[:human genes:u:upf1|UPF1]]|0.408|
|[[:human genes:p:psmb1|PSMB1]]|0.407|
|[[:human genes:e:exosc9|EXOSC9]]|0.404|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.403|
|[[:human genes:c:ccna2|CCNA2]]|0.402|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 606/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|25/28|
|bone|24/26|
|breast|25/33|
|central nervous system|48/56|
|cervix|2/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|18/20|
|lung|65/75|
|lymphocyte|13/16|
|ovary|20/26|
|pancreas|20/24|
|peripheral nervous system|14/16|
|plasma cell|12/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BRIX1 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>