BTD [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= BTD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BTD
  * **<color #00a2e8>Official Name</color>**: biotinidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=686|686]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43251|P43251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=BTD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20BTD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609019|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene functions to recycle protein-bound biotin by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. The encoded protein has also been shown to have biotinyl transferase activity. Mutations in this gene are associated with biotinidase deficiency. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CN hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|biotinidase activity|
|biotin metabolic process|
|water-soluble vitamin metabolic process|
|vitamin metabolic process|
|coenzyme metabolic process|
|sulfur compound metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|extracellular space|
|small molecule metabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='BTD Expression in NALM6 Cells: 2.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>