C10orf54 [The Human Chemical-Genetic Interaction Map Project]

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======= C10orf54 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VSIR
  * **<color #00a2e8>Official Name</color>**: V-set immunoregulatory receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64115|64115]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7M9|Q9H7M9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C10orf54&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C10orf54|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615608|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of collagen catabolic process|
|negative regulation of CD8-positive, alpha-beta T cell proliferation|
|regulation of collagen catabolic process|
|negative regulation of CD8-positive, alpha-beta T cell activation|
|regulation of CD8-positive, alpha-beta T cell proliferation|
|endopeptidase activator activity|
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|negative regulation of alpha-beta T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|positive regulation of regulatory T cell differentiation|
|negative regulation of interleukin-17 production|
|regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of interleukin-10 production|
|positive regulation of collagen metabolic process|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of interleukin-17 production|
|regulation of alpha-beta T cell proliferation|
|regulation of regulatory T cell differentiation|
|negative regulation of interferon-gamma production|
|negative regulation of alpha-beta T cell activation|
|regulation of collagen metabolic process|
|zymogen activation|
|regulation of interleukin-10 production|
|negative regulation of tumor necrosis factor production|
|negative regulation of T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|positive regulation of T cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|regulation of interferon-gamma production|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|protein processing|
|regulation of lymphocyte differentiation|
|positive regulation of endopeptidase activity|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|positive regulation of hemopoiesis|
|positive regulation of peptidase activity|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|protein maturation|
|positive regulation of cell-cell adhesion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|enzyme binding|
|positive regulation of proteolysis|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of hemopoiesis|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|regulation of leukocyte activation|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|identical protein binding|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C10ORF54 Expression in NALM6 Cells: -0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>