C11orf83 [The Human Chemical-Genetic Interaction Map Project]

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======= C11orf83 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCC3
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase complex assembly factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=790955|790955]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UW78|Q6UW78]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C11orf83&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C11orf83|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616097|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin- binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex III assembly|
|respiratory chain complex III assembly|
|cardiolipin binding|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|phosphatidic acid binding|
|cristae formation|
|cytochrome complex assembly|
|ATP biosynthetic process|
|integral component of mitochondrial inner membrane|
|inner mitochondrial membrane organization|
|purine ribonucleoside triphosphate biosynthetic process|
|purine nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|purine ribonucleoside triphosphate metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|nucleoside triphosphate metabolic process|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular respiration|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|cellular protein-containing complex assembly|
|membrane organization|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.75|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.429|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2368
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C11ORF83 Expression in NALM6 Cells: 4.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>