C14orf166 [The Human Chemical-Genetic Interaction Map Project]

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======= C14orf166 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RTRAF
  * **<color #00a2e8>Official Name</color>**: RNA transcription, translation and transport factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51637|51637]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y224|Q9Y224]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C14orf166&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C14orf166|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610858|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264). {ECO:0000269|PubMed:16950395, ECO:0000269|PubMed:24608264, ECO:0000269|PubMed:24870230}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RLL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA-splicing ligase complex|
|tRNA splicing, via endonucleolytic cleavage and ligation|
|RNA splicing, via endonucleolytic cleavage and ligation|
|RNA polymerase II complex binding|
|mitotic spindle|
|tRNA processing|
|tRNA metabolic process|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|negative regulation of protein kinase activity|
|nucleobase-containing compound transport|
|negative regulation of kinase activity|
|negative regulation of transferase activity|
|ncRNA processing|
|RNA splicing|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|ncRNA metabolic process|
|centrosome|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|perinuclear region of cytoplasm|
|viral process|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|RNA processing|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of transcription by RNA polymerase II|
|RNA binding|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.74|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.75|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.82|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddx1|DDX1]]|0.506|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.49|
|[[:human genes:r:rtcb|RTCB]]|0.484|
|[[:human genes:t:thg1l|THG1L]]|0.48|
|[[:human genes:t:tsen34|TSEN34]]|0.476|
|[[:human genes:e:eef1e1|EEF1E1]]|0.457|
|[[:human genes:a:atxn10|ATXN10]]|0.421|
|[[:human genes:r:rpp21|RPP21]]|0.418|
|[[:human genes:r:rabggtb|RABGGTB]]|0.415|
|[[:human genes:a:alg1|ALG1]]|0.412|
|[[:human genes:h:hars|HARS]]|0.412|
|[[:human genes:a:alg2|ALG2]]|0.411|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:t:tsen54|TSEN54]]|0.407|
|[[:human genes:e:exoc4|EXOC4]]|0.406|
|[[:human genes:e:elp2|ELP2]]|0.406|
|[[:human genes:u:uap1|UAP1]]|0.403|
|[[:human genes:g:gmppb|GMPPB]]|0.401|
|[[:human genes:a:adsl|ADSL]]|0.4|
|[[:human genes:d:dpagt1|DPAGT1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 48/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|2/26|
|breast|3/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1459
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C14ORF166 Expression in NALM6 Cells: 6.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>