C14orf2 [The Human Chemical-Genetic Interaction Map Project]

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======= C14orf2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ATP5MPL
  * **<color #00a2e8>Official Name</color>**: ATP synthase membrane subunit 6.8PL
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9556|9556]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56378|P56378]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C14orf2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C14orf2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mit proteolip|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial proton-transporting ATP synthase complex|
|cellular component|
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.8|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.71|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.71|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.77|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.8|
|[[:results:exp539|42°C R08 exp539]]|1.85|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.9|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.01|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.14|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg5|ALG5]]|0.437|
|[[:human genes:a:atp5a1|ATP5A1]]|0.433|
|[[:human genes:t:trmt10a|TRMT10A]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16687
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C14ORF2 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>