C15orf41 [The Human Chemical-Genetic Interaction Map Project]

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======= C15orf41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C15orf41
  * **<color #00a2e8>Official Name</color>**: chromosome 15 open reading frame 41
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84529|84529]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2V0|Q9Y2V0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C15orf41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C15orf41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with two predicted helix-turn-helix domains. Mutations in this gene were found in families with congenital dyserythropoietic anemia type Ib. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-2.03|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.99|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.77|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.73|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.13|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.25|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.38|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.54|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.622|
|[[:human genes:g:gemin6|GEMIN6]]|0.556|
|[[:human genes:t:thg1l|THG1L]]|0.536|
|[[:human genes:h:hars|HARS]]|0.522|
|[[:human genes:t:ten1|TEN1]]|0.519|
|[[:human genes:p:ptar1|PTAR1]]|0.517|
|[[:human genes:r:rpia|RPIA]]|0.512|
|[[:human genes:r:rft1|RFT1]]|0.508|
|[[:human genes:p:ppcs|PPCS]]|0.507|
|[[:human genes:r:rabggtb|RABGGTB]]|0.506|
|[[:human genes:a:atic|ATIC]]|0.505|
|[[:human genes:c:ctc1|CTC1]]|0.493|
|[[:human genes:u:urm1|URM1]]|0.49|
|[[:human genes:r:rtcb|RTCB]]|0.489|
|[[:human genes:e:elp3|ELP3]]|0.488|
|[[:human genes:t:tbcb|TBCB]]|0.487|
|[[:human genes:d:dr1|DR1]]|0.484|
|[[:human genes:t:tprkb|TPRKB]]|0.478|
|[[:human genes:p:pgm3|PGM3]]|0.476|
|[[:human genes:g:gemin7|GEMIN7]]|0.475|
|[[:human genes:s:srp14|SRP14]]|0.472|
|[[:human genes:r:rad50|RAD50]]|0.468|
|[[:human genes:p:ppp6c|PPP6C]]|0.468|
|[[:human genes:p:ppp4c|PPP4C]]|0.467|
|[[:human genes:v:vezt|VEZT]]|0.467|
|[[:human genes:a:atxn10|ATXN10]]|0.467|
|[[:human genes:f:fh|FH]]|0.466|
|[[:human genes:m:msto1|MSTO1]]|0.465|
|[[:human genes:a:adsl|ADSL]]|0.465|
|[[:human genes:r:rpp21|RPP21]]|0.462|
|[[:human genes:l:lsm10|LSM10]]|0.461|
|[[:human genes:t:tpk1|TPK1]]|0.461|
|[[:human genes:a:alg1|ALG1]]|0.458|
|[[:human genes:s:slc25a19|SLC25A19]]|0.457|
|[[:human genes:t:ttc4|TTC4]]|0.456|
|[[:human genes:t:tube1|TUBE1]]|0.45|
|[[:human genes:t:tsen54|TSEN54]]|0.45|
|[[:human genes:z:zrsr2|ZRSR2]]|0.447|
|[[:human genes:d:dolk|DOLK]]|0.446|
|[[:human genes:r:rfk|RFK]]|0.446|
|[[:human genes:d:dhrsx|DHRSX]]|0.446|
|[[:human genes:p:pmvk|PMVK]]|0.445|
|[[:human genes:d:dnlz|DNLZ]]|0.443|
|[[:human genes:z:zcrb1|ZCRB1]]|0.443|
|[[:human genes:s:snapc5|SNAPC5]]|0.442|
|[[:human genes:u:uap1|UAP1]]|0.441|
|[[:human genes:p:pdcd5|PDCD5]]|0.439|
|[[:human genes:p:ppcdc|PPCDC]]|0.438|
|[[:human genes:g:gemin4|GEMIN4]]|0.438|
|[[:human genes:s:srd5a3|SRD5A3]]|0.438|
|[[:human genes:m:mocs3|MOCS3]]|0.437|
|[[:human genes:g:gmppb|GMPPB]]|0.437|
|[[:human genes:t:tubd1|TUBD1]]|0.43|
|[[:human genes:u:uhrf1|UHRF1]]|0.429|
|[[:human genes:n:n6amt1|N6AMT1]]|0.428|
|[[:human genes:d:ddx55|DDX55]]|0.42|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.417|
|[[:human genes:d:ddx39a|DDX39A]]|0.417|
|[[:human genes:t:tamm41|TAMM41]]|0.417|
|[[:human genes:d:ddx1|DDX1]]|0.416|
|[[:human genes:t:trmt6|TRMT6]]|0.414|
|[[:human genes:d:dohh|DOHH]]|0.414|
|[[:human genes:c:cxorf56|CXorf56]]|0.413|
|[[:human genes:m:mrps14|MRPS14]]|0.412|
|[[:human genes:f:fkbpl|FKBPL]]|0.412|
|[[:human genes:p:ppa1|PPA1]]|0.41|
|[[:human genes:d:dpagt1|DPAGT1]]|0.407|
|[[:human genes:s:ssb|SSB]]|0.406|
|[[:human genes:t:tsen34|TSEN34]]|0.405|
|[[:human genes:r:rptor|RPTOR]]|0.404|
|[[:human genes:t:trmt61a|TRMT61A]]|0.404|
|[[:human genes:g:gclc|GCLC]]|0.404|
|[[:human genes:n:nbn|NBN]]|0.403|
|[[:human genes:f:fen1|FEN1]]|0.403|
|[[:human genes:z:znhit1|ZNHIT1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 773
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C15orf41 Expression in NALM6 Cells: 7.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>