C16orf80 [The Human Chemical-Genetic Interaction Map Project]

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======= C16orf80 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CFAP20
  * **<color #00a2e8>Official Name</color>**: cilia and flagella associated protein 20
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29105|29105]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6A4|Q9Y6A4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C16orf80&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C16orf80|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617906|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207). {ECO:0000269|PubMed:24414207}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF667|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cilium beat frequency involved in ciliary motility|
|regulation of cilium movement involved in cell motility|
|positive regulation of feeding behavior|
|regulation of cilium beat frequency|
|protein polyglutamylation|
|regulation of cilium movement|
|regulation of cilium-dependent cell motility|
|positive regulation of behavior|
|regulation of feeding behavior|
|peptidyl-glutamic acid modification|
|regulation of microtubule-based movement|
|regulation of behavior|
|motile cilium|
|ciliary basal body|
|centriole|
|cilium|
|regulation of microtubule-based process|
|microtubule|
|cilium assembly|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|organelle assembly|
|peptidyl-amino acid modification|
|regulation of cell motility|
|regulation of locomotion|
|regulation of cellular component movement|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.92|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.8|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.74|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.75|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.76|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.77|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.83|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.87|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.92|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.94|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.98|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.03|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.18|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.2|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.22|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.3|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.51|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.59|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmvk|PMVK]]|0.465|
|[[:human genes:c:cxorf56|CXorf56]]|0.435|
|[[:human genes:g:got2|GOT2]]|0.419|
|[[:human genes:w:wdr89|WDR89]]|0.41|
|[[:human genes:a:atp2b1|ATP2B1]]|0.408|
|[[:human genes:s:slc25a26|SLC25A26]]|0.406|
|[[:human genes:k:kti12|KTI12]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 89/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|6/26|
|breast|6/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|8/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 130
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C16ORF80 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>