C1QBP [The Human Chemical-Genetic Interaction Map Project]

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======= C1QBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C1QBP
  * **<color #00a2e8>Official Name</color>**: complement C1q binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=708|708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q07021|Q07021]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C1QBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C1QBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601269|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. May function to bind initially fluid kininogen-1 to the cell membrane. The secreted form may enhance both extrinsic and intrinsic coagulation pathways. It is postulated that the cell surface form requires docking with transmembrane proteins for downstream signaling which might be specific for a cell-type or response. By acting as C1q receptor is involved in chemotaxis of immature dendritic cells and neutrophils and is proposed to signal through CD209/DC-SIGN on immature dendritic cells, through integrin alpha-4/beta-1 during trophoblast invasion of the decidua, and through integrin beta-1 during endothelial cell adhesion and spreading. Signaling involved in inhibition of innate immune response is implicating the PI3K-AKT/PKB pathway. In mitochondrial translation may be involved in formation of functional 55S mitoribosomes; the function seems to involve its RNA-binding activity. May be involved in the nucleolar ribosome maturation process; the function may involve the exchange of FBL for RRP1 in the association with pre-ribosome particles. Involved in regulation of RNA splicing by inhibiting the RNA-binding capacity of SRSF1 and its phosphorylation. Is required for the nuclear translocation of splicing factor U2AF1L4. Involved in regulation of CDKN2A- and HRK-mediated apoptosis. Stabilizes mitochondrial CDKN2A isoform smARF. May be involved in regulation of FOXC1 transcriptional activity and NFY/CCAAT-binding factor complex-mediated transcription. In infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A. May play a role in antibacterial defense as it can bind to cell surface hyaluronan and inhibit Streptococcus pneumoniae hyaluronate lyase. Involved in replication of Rubella virus. May be involved in modulation of the immune response; ligation by HCV core protein is resulting in suppresion of interleukin-12 production in monocyte-derived dendritic cells. Involved in regulation of antiviral response by inhibiting DDX58- and IFIH1- mediated signaling pathways probably involving its association with MAVS after viral infection. Involved in HIV-1 replication, presumably by contributing to splicing of viral RNA. {ECO:0000269|PubMed:10022843, ECO:0000269|PubMed:10479529, ECO:0000269|PubMed:10722602, ECO:0000269|PubMed:10747014, ECO:0000269|PubMed:11086025, ECO:0000269|PubMed:11859136, ECO:0000269|PubMed:12833064, ECO:0000269|PubMed:15243141, ECO:0000269|PubMed:16140380, ECO:0000269|PubMed:16177118, ECO:0000269|PubMed:17881511, ECO:0000269|PubMed:18676636, ECO:0000269|PubMed:19004836, ECO:0000269|PubMed:19164550, ECO:0000269|PubMed:20810993, ECO:0000269|PubMed:21536856, ECO:0000269|PubMed:21544310, ECO:0000269|PubMed:22700724, ECO:0000269|PubMed:8662673, ECO:0000269|PubMed:8710908, ECO:0000269|PubMed:9461517}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAM33|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adrenergic receptor binding|
|kininogen binding|
|mitochondrial ribosome binding|
|negative regulation of MDA-5 signaling pathway|
|mature ribosome assembly|
|positive regulation of trophoblast cell migration|
|regulation of MDA-5 signaling pathway|
|complement component C1q binding|
|positive regulation of dendritic cell chemotaxis|
|negative regulation of RIG-I signaling pathway|
|regulation of dendritic cell chemotaxis|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|regulation of trophoblast cell migration|
|translation activator activity|
|negative regulation of interleukin-12 production|
|positive regulation of mitochondrial translation|
|blood coagulation, intrinsic pathway|
|regulation of RIG-I signaling pathway|
|negative regulation of mRNA splicing, via spliceosome|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|hyaluronic acid binding|
|negative regulation of defense response to virus|
|positive regulation of neutrophil chemotaxis|
|negative regulation of RNA splicing|
|regulation of mitochondrial translation|
|blood coagulation, fibrin clot formation|
|positive regulation of granulocyte chemotaxis|
|protein activation cascade|
|regulation of mitochondrial gene expression|
|negative regulation of mRNA processing|
|regulation of neutrophil chemotaxis|
|positive regulation of neutrophil migration|
|negative regulation of interferon-gamma production|
|phosphatidylinositol 3-kinase signaling|
|presynaptic active zone|
|regulation of neutrophil migration|
|positive regulation of substrate adhesion-dependent cell spreading|
|regulation of granulocyte chemotaxis|
|regulation of substrate adhesion-dependent cell spreading|
|protein kinase C binding|
|regulation of interleukin-12 production|
|ribosome assembly|
|GABA-ergic synapse|
|phosphatidylinositol-mediated signaling|
|regulation of defense response to virus|
|inositol lipid-mediated signaling|
|positive regulation of reproductive process|
|negative regulation of mRNA metabolic process|
|positive regulation of leukocyte chemotaxis|
|negative regulation of response to biotic stimulus|
|regulation of mRNA splicing, via spliceosome|
|regulation of interferon-gamma production|
|regulation of leukocyte chemotaxis|
|regulation of complement activation|
|negative regulation of immune effector process|
|positive regulation of cell-substrate adhesion|
|positive regulation of translation|
|positive regulation of leukocyte migration|
|regulation of RNA splicing|
|positive regulation of chemotaxis|
|regulation of humoral immune response|
|regulation of mRNA processing|
|positive regulation of cellular amide metabolic process|
|positive regulation of cell morphogenesis involved in differentiation|
|regulation of reproductive process|
|mRNA binding|
|complement activation, classical pathway|
|positive regulation of protein kinase B signaling|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|regulation of leukocyte migration|
|immunoglobulin mediated immune response|
|negative regulation of defense response|
|B cell mediated immunity|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|negative regulation of multi-organism process|
|regulation of protein kinase B signaling|
|ribonucleoprotein complex assembly|
|transcription corepressor activity|
|ribonucleoprotein complex subunit organization|
|lymphocyte mediated immunity|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|blood coagulation|
|coagulation|
|hemostasis|
|ribosome biogenesis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of mRNA metabolic process|
|transcription factor binding|
|humoral immune response|
|glutamatergic synapse|
|regulation of translation|
|negative regulation of response to external stimulus|
|mitochondrial matrix|
|RNA splicing|
|positive regulation of cell adhesion|
|regulation of cellular amide metabolic process|
|negative regulation of immune system process|
|regulation of innate immune response|
|ribonucleoprotein complex biogenesis|
|regulation of immune effector process|
|mRNA processing|
|wound healing|
|regulation of cell morphogenesis|
|regulation of body fluid levels|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of multi-organism process|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of locomotion|
|response to wounding|
|positive regulation of response to external stimulus|
|adaptive immune response|
|cell surface|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of cell adhesion|
|mRNA metabolic process|
|regulation of cytokine production|
|positive regulation of cell death|
|viral process|
|organelle assembly|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|RNA processing|
|regulation of cell motility|
|apoptotic process|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.75|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.87|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acad9|ACAD9]]|0.535|
|[[:human genes:g:grsf1|GRSF1]]|0.529|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.525|
|[[:human genes:n:ndufb9|NDUFB9]]|0.523|
|[[:human genes:p:pet117|PET117]]|0.517|
|[[:human genes:n:ndufa1|NDUFA1]]|0.514|
|[[:human genes:d:ddx28|DDX28]]|0.512|
|[[:human genes:m:mtif2|MTIF2]]|0.512|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.511|
|[[:human genes:n:ndufb11|NDUFB11]]|0.509|
|[[:human genes:p:polg2|POLG2]]|0.508|
|[[:human genes:t:tfb1m|TFB1M]]|0.493|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.493|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.486|
|[[:human genes:n:nubpl|NUBPL]]|0.482|
|[[:human genes:m:mto1|MTO1]]|0.481|
|[[:human genes:n:ndufa2|NDUFA2]]|0.48|
|[[:human genes:p:pet112|PET112]]|0.476|
|[[:human genes:w:wbscr16|WBSCR16]]|0.473|
|[[:human genes:n:ndufs8|NDUFS8]]|0.468|
|[[:human genes:m:malsu1|MALSU1]]|0.464|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.464|
|[[:human genes:m:mrps21|MRPS21]]|0.462|
|[[:human genes:n:nars2|NARS2]]|0.456|
|[[:human genes:m:mrps25|MRPS25]]|0.455|
|[[:human genes:m:mtg1|MTG1]]|0.453|
|[[:human genes:n:ndufb10|NDUFB10]]|0.448|
|[[:human genes:n:ndufs2|NDUFS2]]|0.448|
|[[:human genes:c:cars2|CARS2]]|0.447|
|[[:human genes:n:ndufs5|NDUFS5]]|0.447|
|[[:human genes:n:ndufa3|NDUFA3]]|0.446|
|[[:human genes:t:tars2|TARS2]]|0.445|
|[[:human genes:r:rars2|RARS2]]|0.443|
|[[:human genes:m:mrpl45|MRPL45]]|0.443|
|[[:human genes:f:ftsj2|FTSJ2]]|0.442|
|[[:human genes:s:ssbp1|SSBP1]]|0.439|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.436|
|[[:human genes:f:fastkd2|FASTKD2]]|0.436|
|[[:human genes:n:ndufa11|NDUFA11]]|0.435|
|[[:human genes:l:lars2|LARS2]]|0.435|
|[[:human genes:g:gfm1|GFM1]]|0.435|
|[[:human genes:r:rpusd3|RPUSD3]]|0.434|
|[[:human genes:e:eral1|ERAL1]]|0.431|
|[[:human genes:n:ndufc1|NDUFC1]]|0.431|
|[[:human genes:q:qrsl1|QRSL1]]|0.431|
|[[:human genes:m:mrpl3|MRPL3]]|0.43|
|[[:human genes:n:ndufs1|NDUFS1]]|0.428|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.428|
|[[:human genes:a:aars2|AARS2]]|0.426|
|[[:human genes:d:dap3|DAP3]]|0.426|
|[[:human genes:y:yars2|YARS2]]|0.424|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.423|
|[[:human genes:m:mrpl21|MRPL21]]|0.423|
|[[:human genes:e:ears2|EARS2]]|0.422|
|[[:human genes:p:ptcd3|PTCD3]]|0.422|
|[[:human genes:t:tomm20|TOMM20]]|0.421|
|[[:human genes:n:ndufv2|NDUFV2]]|0.42|
|[[:human genes:n:ndufs7|NDUFS7]]|0.419|
|[[:human genes:n:ndufc2|NDUFC2]]|0.415|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.415|
|[[:human genes:n:nsun4|NSUN4]]|0.415|
|[[:human genes:n:ndufb7|NDUFB7]]|0.414|
|[[:human genes:n:ndufv1|NDUFV1]]|0.412|
|[[:human genes:p:prepl|PREPL]]|0.41|
|[[:human genes:m:mrp63|MRP63]]|0.409|
|[[:human genes:m:mettl17|METTL17]]|0.407|
|[[:human genes:n:ndufb4|NDUFB4]]|0.403|
|[[:human genes:n:ndufa10|NDUFA10]]|0.402|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|2/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 589
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C1QBP Expression in NALM6 Cells: 7.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>