C2CD5 [The Human Chemical-Genetic Interaction Map Project]

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======= C2CD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C2CD5
  * **<color #00a2e8>Official Name</color>**: C2 calcium dependent domain containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9847|9847]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86YS7|Q86YS7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C2CD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C2CD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618044|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|
|positive regulation of vesicle fusion|
|positive regulation of protein targeting to membrane|
|regulation of vesicle fusion|
|regulation of protein targeting to membrane|
|positive regulation of glucose import|
|positive regulation of glucose transmembrane transport|
|intracellular protein transmembrane transport|
|regulation of glucose import|
|calcium-dependent phospholipid binding|
|protein transmembrane transport|
|vesicle fusion|
|regulation of glucose transmembrane transport|
|organelle membrane fusion|
|regulation of protein targeting|
|insulin receptor signaling pathway|
|ruffle membrane|
|organelle fusion|
|positive regulation of protein localization to membrane|
|membrane fusion|
|cell cortex|
|cytoplasmic vesicle membrane|
|positive regulation of intracellular protein transport|
|microtubule organizing center|
|cellular response to insulin stimulus|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|response to insulin|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|cellular response to peptide hormone stimulus|
|vesicle organization|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|regulation of intracellular transport|
|response to peptide hormone|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|response to peptide|
|protein localization to membrane|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|cellular response to nitrogen compound|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|response to hormone|
|regulation of cellular localization|
|positive regulation of transport|
|intracellular protein transport|
|response to organonitrogen compound|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|transmembrane transport|
|regulation of organelle organization|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.14|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.99|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.98|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.95|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.92|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.87|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.86|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.75|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.74|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.74|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.8|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.86|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.89|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.9|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.98|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|2.02|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.08|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.16|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.21|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.41|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.77|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|4.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fibp|FIBP]]|0.615|
|[[:human genes:k:kiaa0195|KIAA0195]]|0.449|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10177
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C2CD5 Expression in NALM6 Cells: 6.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>