C3orf17 [The Human Chemical-Genetic Interaction Map Project]

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======= C3orf17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEPRO
  * **<color #00a2e8>Official Name</color>**: nucleolus and neural progenitor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25871|25871]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NW34|Q6NW34]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C3orf17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C3orf17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. {ECO:0000250|UniProtKB:Q8R2U2}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of Notch signaling pathway|
|regulation of Notch signaling pathway|
|negative regulation of neuron differentiation|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of neuron differentiation|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|nucleolus|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|negative regulation of multicellular organismal process|
|generation of neurons|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-2.15|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.99|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.484|
|[[:human genes:t:tceb3c|TCEB3C]]|0.458|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.448|
|[[:human genes:c:chd4|CHD4]]|0.441|
|[[:human genes:c:c14orf93|C14orf93]]|0.44|
|[[:human genes:p:pole|POLE]]|0.433|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.431|
|[[:human genes:r:rrp7a|RRP7A]]|0.422|
|[[:human genes:n:nol10|NOL10]]|0.42|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.413|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.412|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:r:rps7|RPS7]]|0.411|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.411|
|[[:human genes:a:aamp|AAMP]]|0.411|
|[[:human genes:p:polr2j3|POLR2J3]]|0.41|
|[[:human genes:r:rps2|RPS2]]|0.409|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.406|
|[[:human genes:p:psmb2|PSMB2]]|0.404|
|[[:human genes:l:lrr1|LRR1]]|0.403|
|[[:human genes:r:rps5|RPS5]]|0.403|
|[[:human genes:r:rps10|RPS10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 681/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|26/28|
|bone|26/26|
|breast|28/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|18/20|
|lung|71/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C3ORF17 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>