C4BPA [The Human Chemical-Genetic Interaction Map Project]

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======= C4BPA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C4BPA
  * **<color #00a2e8>Official Name</color>**: complement component 4 binding protein alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=722|722]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04003|P04003]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C4BPA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C4BPA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of opsonization|
|negative regulation of complement activation, classical pathway|
|regulation of complement activation, classical pathway|
|response to symbiont|
|response to symbiotic bacterium|
|negative regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of complement activation|
|negative regulation of B cell mediated immunity|
|negative regulation of immunoglobulin mediated immune response|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|negative regulation of humoral immune response|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|regulation of phagocytosis|
|regulation of complement activation|
|negative regulation of immune effector process|
|regulation of humoral immune response|
|blood microparticle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|regulation of leukocyte mediated immunity|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|positive regulation of protein catabolic process|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|humoral immune response|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|negative regulation of immune system process|
|regulation of immune effector process|
|regulation of vesicle-mediated transport|
|adaptive immune response|
|activation of immune response|
|response to bacterium|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of immune response|
|defense response to other organism|
|regulation of catabolic process|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-1.91|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.73|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.7|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.77|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.83|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.84|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.96|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.19|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C4BPA Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>