C5 [The Human Chemical-Genetic Interaction Map Project]

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======= C5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: C5
  * **<color #00a2e8>Official Name</color>**: complement C5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=727|727]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01031|P01031]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120900|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause complement component 5 deficiency, a disease characterized by recurrent bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|A2M recep|
|A2M N 2|
|A2M comp|
|A2M N|
|ANATO|
|A2M|
|NTR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of macrophage chemotaxis|
|membrane attack complex|
|negative regulation of macrophage migration|
|complement activation, alternative pathway|
|positive regulation of chemokine secretion|
|regulation of chemokine secretion|
|negative regulation of leukocyte chemotaxis|
|cytolysis|
|regulation of macrophage chemotaxis|
|positive regulation of vascular endothelial growth factor production|
|regulation of vascular endothelial growth factor production|
|endopeptidase inhibitor activity|
|regulation of macrophage migration|
|negative regulation of leukocyte migration|
|chemokine activity|
|positive regulation of chemokine production|
|negative regulation of chemotaxis|
|regulation of chemokine production|
|regulation of leukocyte chemotaxis|
|regulation of complement activation|
|regulation of humoral immune response|
|positive regulation of cytokine secretion|
|activation of MAPK activity|
|complement activation, classical pathway|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|regulation of leukocyte migration|
|regulation of cytokine secretion|
|immunoglobulin mediated immune response|
|B cell mediated immunity|
|cell chemotaxis|
|regulation of chemotaxis|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|positive regulation of MAP kinase activity|
|lymphocyte mediated immunity|
|positive regulation of protein secretion|
|negative regulation of cell motility|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of peptide secretion|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|activation of protein kinase activity|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|humoral immune response|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|regulation of peptide secretion|
|inflammatory response|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of kinase activity|
|adaptive immune response|
|activation of immune response|
|positive regulation of transferase activity|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|innate immune response|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|regulation of cell motility|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.74|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10878
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C5 Expression in NALM6 Cells: 2.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>