C5orf42 [The Human Chemical-Genetic Interaction Map Project]

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======= C5orf42 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPLANE1
  * **<color #00a2e8>Official Name</color>**: ciliogenesis and planar polarity effector 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65250|65250]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H799|Q9H799]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C5orf42&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C5orf42|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614571|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). {ECO:0000250|UniProtKB:Q8CE72, ECO:0000305|PubMed:25877302}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to ciliary transition zone|
|establishment of planar polarity|
|establishment of tissue polarity|
|ciliary transition zone|
|morphogenesis of a polarized epithelium|
|coronary vasculature development|
|protein localization to cilium|
|embryonic digit morphogenesis|
|ventricular septum development|
|roof of mouth development|
|cerebellum development|
|cardiac septum development|
|metencephalon development|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac ventricle development|
|appendage morphogenesis|
|limb morphogenesis|
|hindbrain development|
|cardiac chamber development|
|appendage development|
|limb development|
|kidney development|
|renal system development|
|urogenital system development|
|cilium assembly|
|cilium organization|
|morphogenesis of an epithelium|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|tissue morphogenesis|
|embryonic morphogenesis|
|protein localization to organelle|
|brain development|
|organelle assembly|
|head development|
|circulatory system development|
|embryo development|
|central nervous system development|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular protein localization|
|cellular macromolecule localization|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10390
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C5ORF42 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>