C6orf25 [The Human Chemical-Genetic Interaction Map Project]

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======= C6orf25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MPIG6B
  * **<color #00a2e8>Official Name</color>**: megakaryocyte and platelet inhibitory receptor G6b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80739|80739]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95866|O95866]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C6orf25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C6orf25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606520|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). {ECO:0000269|PubMed:12665801, ECO:0000269|PubMed:17311996, ECO:0000269|PubMed:27743390}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|megakaryocyte development|
|platelet formation|
|platelet morphogenesis|
|megakaryocyte differentiation|
|bone cell development|
|myeloid cell development|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|integrin-mediated signaling pathway|
|myeloid cell homeostasis|
|platelet activation|
|heparin binding|
|bone development|
|homeostasis of number of cells|
|myeloid cell differentiation|
|blood coagulation|
|coagulation|
|hemostasis|
|wound healing|
|skeletal system development|
|regulation of body fluid levels|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|response to wounding|
|hematopoietic or lymphoid organ development|
|immune system development|
|cell morphogenesis|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|Golgi apparatus|
|endoplasmic reticulum|
|cell activation|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.93|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C6ORF25 Expression in NALM6 Cells: 3.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>