C9orf114 [The Human Chemical-Genetic Interaction Map Project]

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======= C9orf114 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SPOUT1
  * **<color #00a2e8>Official Name</color>**: SPOUT domain containing methyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51490|51490]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T280|Q5T280]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=C9orf114&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20C9orf114|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:20813266, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:28431233}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF171|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of centrosome location|
|maintenance of organelle location|
|spindle pole centrosome|
|production of miRNAs involved in gene silencing by miRNA|
|centrosome localization|
|microtubule organizing center localization|
|miRNA binding|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|gene silencing by miRNA|
|methyltransferase activity|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|mitotic spindle|
|kinetochore|
|gene silencing by RNA|
|condensed chromosome kinetochore|
|maintenance of location in cell|
|gene silencing|
|maintenance of location|
|regulation of gene expression, epigenetic|
|methylation|
|cell division|
|posttranscriptional regulation of gene expression|
|organelle localization|
|RNA processing|
|cell cycle|
|RNA binding|
|RNA metabolic process|
|negative regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.39|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.94|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.92|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.494|
|[[:human genes:p:polr2j3|POLR2J3]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 730/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 460
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='C9ORF114 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>