CACNA1B [The Human Chemical-Genetic Interaction Map Project]

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======= CACNA1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNA1B
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel subunit alpha1 B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=774|774]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00975|Q00975]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNA1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNA1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601012|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PKD channel|
|Ion trans|
|Ca chan IQ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|high voltage-gated calcium channel activity|
|voltage-gated calcium channel complex|
|response to pain|
|voltage-gated calcium channel activity|
|calcium ion import|
|response to amyloid-beta|
|membrane depolarization|
|multicellular organismal response to stress|
|amyloid-beta binding|
|presynapse|
|signal release from synapse|
|neurotransmitter secretion|
|signal release|
|neurotransmitter transport|
|regulation of blood pressure|
|protein C-terminus binding|
|locomotory behavior|
|calcium ion transmembrane transport|
|regulation of heart contraction|
|regulation of calcium ion transport|
|calcium ion transport|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of neurotransmitter levels|
|neuronal cell body|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|dendrite|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|regulation of membrane potential|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|response to peptide|
|regulation of ion transmembrane transport|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|calcium ion binding|
|cation transport|
|ion transmembrane transport|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|response to nitrogen compound|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|ATP binding|
|response to oxygen-containing compound|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNA1B Expression in NALM6 Cells: 1.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>