CACNG7 [The Human Chemical-Genetic Interaction Map Project]

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======= CACNG7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CACNG7
  * **<color #00a2e8>Official Name</color>**: calcium voltage-gated channel auxiliary subunit gamma 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59284|59284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62955|P62955]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CACNG7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CACNG7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606899|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:21172611}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PMP22 Claudin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar mossy fiber|
|neurotransmitter receptor transport, postsynaptic endosome to lysosome|
|channel regulator activity|
|postsynaptic neurotransmitter receptor diffusion trapping|
|receptor diffusion trapping|
|neurotransmitter receptor diffusion trapping|
|L-type voltage-gated calcium channel complex|
|protein localization to postsynaptic specialization membrane|
|neurotransmitter receptor internalization|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|postsynaptic density membrane|
|positive regulation of dendrite extension|
|regulation of dendrite extension|
|regulation of AMPA receptor activity|
|AMPA glutamate receptor complex|
|voltage-gated calcium channel complex|
|positive regulation of synaptic transmission, glutamatergic|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|calcium channel regulator activity|
|protein localization to lysosome|
|voltage-gated calcium channel activity|
|receptor localization to synapse|
|establishment of protein localization to vacuole|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|integral component of postsynaptic density membrane|
|transmission of nerve impulse|
|protein localization to vacuole|
|receptor internalization|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|regulation of synaptic transmission, glutamatergic|
|regulation of neurotransmitter receptor activity|
|localization within membrane|
|cardiac conduction|
|receptor metabolic process|
|lysosomal transport|
|multicellular organismal signaling|
|vacuolar transport|
|positive regulation of synaptic transmission|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of mRNA stability|
|regulation of RNA stability|
|calcium ion transmembrane transport|
|regulation of mRNA catabolic process|
|protein localization to cell periphery|
|receptor-mediated endocytosis|
|regulation of heart contraction|
|calcium ion transport|
|protein-containing complex localization|
|early endosome|
|regulation of ion transmembrane transporter activity|
|positive regulation of growth|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|regulation of blood circulation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of mRNA metabolic process|
|regulation of developmental growth|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|regulation of cell growth|
|establishment of protein localization to organelle|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|positive regulation of cell development|
|endocytosis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|regulation of growth|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of neurogenesis|
|cation transport|
|regulation of cellular catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|regulation of catabolic process|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|protein transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11120
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CACNG7 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>