CADPS2 [The Human Chemical-Genetic Interaction Map Project]

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======= CADPS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CADPS2
  * **<color #00a2e8>Official Name</color>**: calcium dependent secretion activator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=93664|93664]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UW7|Q86UW7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CADPS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CADPS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609978|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1041|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dense core granule exocytosis|
|synaptic vesicle priming|
|parallel fiber to Purkinje cell synapse|
|calcium-ion regulated exocytosis|
|synaptic vesicle exocytosis|
|exocytic process|
|presynaptic membrane|
|positive regulation of exocytosis|
|neurotransmitter secretion|
|signal release from synapse|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|cytoplasmic vesicle membrane|
|cellular response to starvation|
|lipid binding|
|signal release|
|neurotransmitter transport|
|response to starvation|
|postsynaptic membrane|
|regulation of exocytosis|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of secretion|
|trans-synaptic signaling|
|synaptic signaling|
|response to nutrient levels|
|response to extracellular stimulus|
|cell junction|
|regulation of vesicle-mediated transport|
|intracellular membrane-bounded organelle|
|regulated exocytosis|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|cellular protein-containing complex assembly|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|protein transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.73|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.76|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9267
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CADPS2 Expression in NALM6 Cells: -1.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>