CAMLG [The Human Chemical-Genetic Interaction Map Project]

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======= CAMLG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CAMLG
  * **<color #00a2e8>Official Name</color>**: calcium modulating ligand
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=819|819]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49069|P49069]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CAMLG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CAMLG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|receptor recycling|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of ubiquitin-dependent protein catabolic process|
|epidermal growth factor receptor signaling pathway|
|negative regulation of proteasomal protein catabolic process|
|cell adhesion molecule binding|
|ERBB signaling pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of protein ubiquitination|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of cellular protein catabolic process|
|receptor metabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|protein stabilization|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|negative regulation of protein modification process|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|defense response|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.72|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.38|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.99|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.85|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.85|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.82|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin7|GEMIN7]]|0.416|
|[[:human genes:w:wrb|WRB]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3566
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CAMLG Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>