CBX3 [The Human Chemical-Genetic Interaction Map Project]

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======= CBX3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CBX3
  * **<color #00a2e8>Official Name</color>**: chromobox 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11335|11335]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13185|Q13185]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CBX3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CBX3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604477|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:28167679}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Chromo shadow|
|Chromo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone methyltransferase binding|
|condensed chromosome, centromeric region|
|nuclear pericentric heterochromatin|
|site of DNA damage|
|nuclear heterochromatin|
|nuclear euchromatin|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|nuclear inner membrane|
|chromosome, centromeric region|
|nuclear chromosome, telomeric region|
|chromatin|
|spindle|
|chromatin remodeling|
|nuclear envelope|
|protein domain specific binding|
|rhythmic process|
|negative regulation of cell cycle process|
|enzyme binding|
|negative regulation of cell cycle|
|chromatin organization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|chromosome organization|
|identical protein binding|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.33|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.24|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.1|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.09|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.07|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.99|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.96|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.96|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.95|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.93|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.9|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.89|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.89|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.88|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.87|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.85|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.84|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.83|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.81|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.8|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.8|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.71|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.73|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.77|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.86|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.86|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.88|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.01|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.1|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.2|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.24|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.26|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.53|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.61|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.62|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.7|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.73|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.8|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|5.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atf7ip|ATF7IP]]|0.596|
|[[:human genes:a:arl14ep|ARL14EP]]|0.552|
|[[:human genes:t:thoc6|THOC6]]|0.502|
|[[:human genes:t:trmt5|TRMT5]]|0.502|
|[[:human genes:o:otud5|OTUD5]]|0.498|
|[[:human genes:b:bap1|BAP1]]|0.495|
|[[:human genes:s:setdb1|SETDB1]]|0.495|
|[[:human genes:m:med23|MED23]]|0.494|
|[[:human genes:p:ppp6c|PPP6C]]|0.493|
|[[:human genes:t:trip12|TRIP12]]|0.492|
|[[:human genes:i:id3|ID3]]|0.488|
|[[:human genes:m:mllt1|MLLT1]]|0.479|
|[[:human genes:c:ccdc101|CCDC101]]|0.477|
|[[:human genes:t:trim28|TRIM28]]|0.475|
|[[:human genes:d:dpagt1|DPAGT1]]|0.468|
|[[:human genes:c:cbfb|CBFB]]|0.463|
|[[:human genes:t:tle4|TLE4]]|0.463|
|[[:human genes:t:triap1|TRIAP1]]|0.461|
|[[:human genes:p:pmm2|PMM2]]|0.458|
|[[:human genes:m:mapk14|MAPK14]]|0.455|
|[[:human genes:a:asb7|ASB7]]|0.454|
|[[:human genes:g:glmn|GLMN]]|0.453|
|[[:human genes:z:zmym2|ZMYM2]]|0.451|
|[[:human genes:t:tti1|TTI1]]|0.45|
|[[:human genes:r:rpe|RPE]]|0.449|
|[[:human genes:t:tti2|TTI2]]|0.449|
|[[:human genes:u:uhrf1|UHRF1]]|0.448|
|[[:human genes:u:ubr5|UBR5]]|0.448|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.447|
|[[:human genes:s:slc25a26|SLC25A26]]|0.446|
|[[:human genes:l:lcmt1|LCMT1]]|0.446|
|[[:human genes:z:znf445|ZNF445]]|0.442|
|[[:human genes:a:aars|AARS]]|0.439|
|[[:human genes:t:tmem41b|TMEM41B]]|0.438|
|[[:human genes:t:thg1l|THG1L]]|0.437|
|[[:human genes:r:rptor|RPTOR]]|0.437|
|[[:human genes:a:alg5|ALG5]]|0.435|
|[[:human genes:w:wdr24|WDR24]]|0.435|
|[[:human genes:a:actb|ACTB]]|0.434|
|[[:human genes:p:ppp2r2a|PPP2R2A]]|0.433|
|[[:human genes:t:tceb3|TCEB3]]|0.431|
|[[:human genes:a:asxl2|ASXL2]]|0.424|
|[[:human genes:f:fh|FH]]|0.424|
|[[:human genes:l:lsm10|LSM10]]|0.424|
|[[:human genes:t:ttc4|TTC4]]|0.424|
|[[:human genes:d:dohh|DOHH]]|0.42|
|[[:human genes:u:ube2l3|UBE2L3]]|0.419|
|[[:human genes:n:nsd1|NSD1]]|0.419|
|[[:human genes:m:maml1|MAML1]]|0.417|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.417|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.414|
|[[:human genes:a:ago2|AGO2]]|0.414|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.411|
|[[:human genes:d:dhx29|DHX29]]|0.41|
|[[:human genes:s:stt3a|STT3A]]|0.408|
|[[:human genes:v:vezt|VEZT]]|0.406|
|[[:human genes:m:med25|MED25]]|0.406|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.406|
|[[:human genes:r:rnmt|RNMT]]|0.405|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.405|
|[[:human genes:a:ambra1|AMBRA1]]|0.403|
|[[:human genes:c:chchd4|CHCHD4]]|0.403|
|[[:human genes:a:atxn10|ATXN10]]|0.402|
|[[:human genes:d:dcaf5|DCAF5]]|0.402|
|[[:human genes:a:alg1|ALG1]]|0.401|
|[[:human genes:s:ssb|SSB]]|0.401|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4431
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CBX3 Expression in NALM6 Cells: 8.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>