CCAR2 [The Human Chemical-Genetic Interaction Map Project]

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======= CCAR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCAR2
  * **<color #00a2e8>Official Name</color>**: cell cycle and apoptosis regulator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57805|57805]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N163|Q8N163]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCAR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCAR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607359|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of DNA damage checkpoint|
|DBIRD complex|
|positive regulation of cell cycle checkpoint|
|mitochondrial fragmentation involved in apoptotic process|
|regulation of DNA damage checkpoint|
|enzyme inhibitor activity|
|regulation of cell cycle checkpoint|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|RNA polymerase II complex binding|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of protein deacetylation|
|negative regulation of ubiquitin-dependent protein catabolic process|
|regulation of DNA-templated transcription, elongation|
|negative regulation of proteasomal protein catabolic process|
|apoptotic mitochondrial changes|
|nuclear receptor transcription coactivator activity|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular response to heat|
|negative regulation of response to DNA damage stimulus|
|negative regulation of cellular protein catabolic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of response to DNA damage stimulus|
|regulation of circadian rhythm|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of protein catabolic process|
|response to UV|
|positive regulation of canonical Wnt signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of Wnt signaling pathway|
|negative regulation of cell growth|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to DNA damage stimulus|
|negative regulation of apoptotic signaling pathway|
|nuclear chromatin|
|negative regulation of growth|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|rhythmic process|
|regulation of canonical Wnt signaling pathway|
|regulation of protein stability|
|response to light stimulus|
|negative regulation of catabolic process|
|enzyme binding|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|mitochondrial matrix|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|RNA splicing|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|response to radiation|
|mitochondrion organization|
|mRNA processing|
|negative regulation of intracellular signal transduction|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|mRNA metabolic process|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|regulation of catabolic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.02|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.93|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.93|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.85|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.84|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.76|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.86|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.45|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2523
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCAR2 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>