CCDC18 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCDC18
  * **<color #00a2e8>Official Name</color>**: coiled-coil domain containing 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=343099|343099]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T9S5|Q5T9S5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621137|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.96|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.93|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.91|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.81|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.72|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.79|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.8|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.8|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.81|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.82|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|1.84|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.92|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.96|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.16|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.25|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.26|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.45|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC18 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>