CCDC41 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC41 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP83
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 83
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51134|51134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y592|Q9Y592]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC41&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC41|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615847|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a centriolar protein involved in primary cilium assembly. Defects in this gene have been associated with infantile nephronophthisis and intellectual disability. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly. {ECO:0000269|PubMed:23348840, ECO:0000269|PubMed:23530209}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ciliary transition fiber|
|establishment of centrosome localization|
|protein localization to centrosome|
|protein localization to microtubule organizing center|
|centrosome localization|
|microtubule organizing center localization|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|vesicle docking|
|ciliary basal body-plasma membrane docking|
|centriole|
|organelle localization by membrane tethering|
|membrane docking|
|cilium assembly|
|establishment of organelle localization|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organelle localization|
|protein localization to organelle|
|organelle assembly|
|molecular function|
|Golgi apparatus|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.03|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.94|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.8|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.76|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.89|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.9|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.93|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.98|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.21|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.36|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.6|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.64|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|6.58|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|7.41|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|7.65|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:casp2|CASP2]]|0.699|
|[[:human genes:o:ofd1|OFD1]]|0.661|
|[[:human genes:p:pibf1|PIBF1]]|0.661|
|[[:human genes:c:c2cd3|C2CD3]]|0.66|
|[[:human genes:o:odf2|ODF2]]|0.644|
|[[:human genes:c:cradd|CRADD]]|0.636|
|[[:human genes:c:cep76|CEP76]]|0.627|
|[[:human genes:p:pidd|PIDD]]|0.621|
|[[:human genes:c:cep78|CEP78]]|0.587|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.582|
|[[:human genes:c:c16orf59|C16orf59]]|0.565|
|[[:human genes:s:sclt1|SCLT1]]|0.558|
|[[:human genes:t:tubd1|TUBD1]]|0.553|
|[[:human genes:n:nin|NIN]]|0.548|
|[[:human genes:a:ankrd26|ANKRD26]]|0.547|
|[[:human genes:c:cep128|CEP128]]|0.544|
|[[:human genes:c:c14orf80|C14orf80]]|0.541|
|[[:human genes:c:cep120|CEP120]]|0.535|
|[[:human genes:f:fopnl|FOPNL]]|0.531|
|[[:human genes:c:cep44|CEP44]]|0.515|
|[[:human genes:h:hyls1|HYLS1]]|0.483|
|[[:human genes:t:tube1|TUBE1]]|0.448|
|[[:human genes:k:kiaa0586|KIAA0586]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13143
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC41 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>