CCDC67 [The Human Chemical-Genetic Interaction Map Project]

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======= CCDC67 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DEUP1
  * **<color #00a2e8>Official Name</color>**: deuterosome assembly protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=159989|159989]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q05D60|Q05D60]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCDC67&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCDC67|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617148|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deuterosome|
|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|
|de novo centriole assembly|
|multi-ciliated epithelial cell differentiation|
|centriole replication|
|centriole assembly|
|centrosome duplication|
|centrosome cycle|
|microtubule organizing center organization|
|centriole|
|microtubule cytoskeleton organization|
|microtubule-based process|
|epithelial cell differentiation|
|organelle assembly|
|cell cycle process|
|identical protein binding|
|cytoskeleton organization|
|epithelium development|
|cell projection organization|
|cell cycle|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.22|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.74|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.78|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.04|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2.07|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.26|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13863
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCDC67 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>