CCL3 [The Human Chemical-Genetic Interaction Map Project]

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======= CCL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCL3
  * **<color #00a2e8>Official Name</color>**: C-C motif chemokine ligand 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6348|6348]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10147|P10147]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182283|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent protein kinase C activity|
|eosinophil mediated immunity|
|eosinophil degranulation|
|eosinophil activation involved in immune response|
|eosinophil activation|
|CCR1 chemokine receptor binding|
|positive regulation of microglial cell migration|
|astrocyte cell migration|
|positive regulation of natural killer cell chemotaxis|
|regulation of microglial cell migration|
|CCR5 chemokine receptor binding|
|phospholipase activator activity|
|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|regulation of natural killer cell chemotaxis|
|positive regulation of microglial cell activation|
|release of sequestered calcium ion into cytosol by endoplasmic reticulum|
|positive regulation of glial cell migration|
|T cell chemotaxis|
|macrophage chemotaxis|
|positive regulation of neuroinflammatory response|
|negative regulation by host of viral transcription|
|sarcoplasmic reticulum calcium ion transport|
|regulation of glial cell migration|
|regulation of microglial cell activation|
|negative regulation of bone mineralization|
|macrophage migration|
|positive regulation of macrophage migration|
|positive regulation of calcium ion import|
|eosinophil chemotaxis|
|positive regulation of lymphocyte chemotaxis|
|eosinophil migration|
|positive regulation of macrophage activation|
|response to cholesterol|
|regulation of lymphocyte chemotaxis|
|negative regulation of viral transcription|
|negative regulation of osteoclast differentiation|
|T cell migration|
|negative regulation of biomineral tissue development|
|negative regulation of biomineralization|
|CCR chemokine receptor binding|
|response to sterol|
|regulation of neuroinflammatory response|
|positive regulation of interleukin-1 beta secretion|
|lipopolysaccharide-mediated signaling pathway|
|chemoattractant activity|
|glial cell migration|
|regulation of macrophage migration|
|positive regulation of lymphocyte migration|
|positive regulation of interleukin-1 secretion|
|protein kinase B signaling|
|regulation of sensory perception of pain|
|regulation of calcium ion import|
|regulation of sensory perception|
|monocyte chemotaxis|
|positive regulation of calcium-mediated signaling|
|negative regulation of myeloid leukocyte differentiation|
|regulation of interleukin-1 beta secretion|
|lymphocyte chemotaxis|
|positive chemotaxis|
|mononuclear cell migration|
|chemokine activity|
|positive regulation of interleukin-1 beta production|
|regulation of macrophage activation|
|positive regulation of neuron apoptotic process|
|regulation of interleukin-1 secretion|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|positive regulation of interleukin-1 production|
|regulation of lymphocyte migration|
|regulation of viral transcription|
|regulation of osteoclast differentiation|
|lymphocyte migration|
|calcium ion transmembrane import into cytosol|
|positive regulation of gliogenesis|
|modification by host of symbiont morphology or physiology|
|regulation of behavior|
|negative regulation of ossification|
|calcium ion transport into cytosol|
|regulation of bone mineralization|
|interaction with symbiont|
|negative regulation of myeloid cell differentiation|
|kinase activity|
|chemokine-mediated signaling pathway|
|regulation of interleukin-1 beta production|
|neutrophil chemotaxis|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cytosolic calcium ion transport|
|response to chemokine|
|cellular response to chemokine|
|neutrophil migration|
|positive regulation of neuron death|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|regulation of interleukin-1 production|
|regulation of calcium-mediated signaling|
|negative regulation of viral process|
|negative regulation of leukocyte differentiation|
|granulocyte migration|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of leukocyte chemotaxis|
|regulation of myeloid leukocyte differentiation|
|regulation of gliogenesis|
|positive regulation of calcium ion transport|
|regulation of sequestering of calcium ion|
|osteoblast differentiation|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|negative regulation of hemopoiesis|
|regulation of nervous system process|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|regulation of tumor necrosis factor production|
|regulation of cell shape|
|regulation of tumor necrosis factor superfamily cytokine production|
|modification of morphology or physiology of other organism|
|cellular response to interferon-gamma|
|positive regulation of protein kinase B signaling|
|cellular response to interleukin-1|
|response to interferon-gamma|
|cellular response to lipopolysaccharide|
|regulation of ossification|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|calcium ion transmembrane transport|
|response to interleukin-1|
|regulation of cytokine secretion|
|regulation of viral process|
|regulation of neuron apoptotic process|
|cell chemotaxis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|negative regulation of multi-organism process|
|cellular response to biotic stimulus|
|regulation of protein kinase B signaling|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of myeloid cell differentiation|
|response to alcohol|
|protein kinase activity|
|cellular response to tumor necrosis factor|
|regulation of calcium ion transport|
|calcium ion transport|
|ossification|
|response to tumor necrosis factor|
|positive regulation of protein secretion|
|regulation of leukocyte differentiation|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of neuron death|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|MAPK cascade|
|leukocyte migration|
|regulation of metal ion transport|
|signal transduction by protein phosphorylation|
|positive regulation of leukocyte activation|
|positive regulation of secretion by cell|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|regulation of hemopoiesis|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|myeloid leukocyte activation|
|regulation of system process|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of programmed cell death|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|cation transport|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|ion transmembrane transport|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|transmembrane transport|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.7|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10055
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCL3 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>