CCNT2 [The Human Chemical-Genetic Interaction Map Project]

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======= CCNT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCNT2
  * **<color #00a2e8>Official Name</color>**: cyclin T2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=905|905]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60583|O60583]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCNT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCNT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603862|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). {ECO:0000250|UniProtKB:Q7TQK0, ECO:0000269|PubMed:11713533, ECO:0000269|PubMed:15563843, ECO:0000269|PubMed:16331689, ECO:0000269|PubMed:9499409}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cyclin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|early viral transcription|
|late viral transcription|
|7SK snRNA binding|
|cyclin/CDK positive transcription elongation factor complex|
|cyclin-dependent protein serine/threonine kinase activator activity|
|RNA polymerase binding|
|transcription coactivator binding|
|positive regulation of DNA-templated transcription, elongation|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|cyclin-dependent protein serine/threonine kinase regulator activity|
|positive regulation of cyclin-dependent protein kinase activity|
|regulation of DNA-templated transcription, elongation|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|viral transcription|
|skeletal muscle tissue development|
|viral gene expression|
|skeletal muscle organ development|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of cell cycle|
|chromatin binding|
|muscle structure development|
|transcription by RNA polymerase II|
|cell division|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|positive regulation of kinase activity|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|positive regulation of transferase activity|
|perinuclear region of cytoplasm|
|viral process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of kinase activity|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8433
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCNT2 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>