CCS [The Human Chemical-Genetic Interaction Map Project]

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======= CCS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCS
  * **<color #00a2e8>Official Name</color>**: copper chaperone for superoxide dismutase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9973|9973]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14618|O14618]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603864|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Delivers copper to copper zinc superoxide dismutase (SOD1).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sod Cu|
|HMA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein maturation by copper ion transfer|
|superoxide dismutase copper chaperone activity|
|superoxide dismutase activity|
|removal of superoxide radicals|
|cellular response to oxygen radical|
|cellular response to superoxide|
|response to superoxide|
|response to oxygen radical|
|protein disulfide oxidoreductase activity|
|superoxide metabolic process|
|positive regulation of oxidoreductase activity|
|copper ion binding|
|cellular oxidant detoxification|
|regulation of oxidoreductase activity|
|cellular detoxification|
|reactive oxygen species metabolic process|
|detoxification|
|cellular response to reactive oxygen species|
|response to reactive oxygen species|
|cellular response to toxic substance|
|protein maturation|
|cellular response to oxidative stress|
|cadherin binding|
|response to oxidative stress|
|response to toxic substance|
|response to inorganic substance|
|metal ion transport|
|cation transport|
|oxidation-reduction process|
|cellular response to oxygen-containing compound|
|ion transport|
|positive regulation of catalytic activity|
|response to oxygen-containing compound|
|cellular response to stress|
|positive regulation of molecular function|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.23|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.04|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5140
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCS Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>