CCZ1 [The Human Chemical-Genetic Interaction Map Project]

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======= CCZ1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCZ1
  * **<color #00a2e8>Official Name</color>**: CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51622|51622]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P86791|P86791]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CCZ1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CCZ1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1712|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Mon1-Ccz1 complex|
|aggresome|
|guanyl-nucleotide exchange factor activity|
|lysosomal membrane|
|intracellular membrane-bounded organelle|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.84|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.89|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.96|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|2|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.05|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.09|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.12|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.13|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.32|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.37|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.69|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c18orf8|C18orf8]]|0.431|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CCZ1 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>