CD22 [The Human Chemical-Genetic Interaction Map Project]

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======= CD22 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD22
  * **<color #00a2e8>Official Name</color>**: CD22 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=933|933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20273|P20273]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD22&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD22|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107266|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|I-set|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IgM binding|
|negative regulation of immunoglobulin secretion|
|negative regulation of B cell receptor signaling pathway|
|CD4 receptor binding|
|negative regulation of immunoglobulin production|
|sialic acid binding|
|regulation of immunoglobulin secretion|
|regulation of B cell receptor signaling pathway|
|negative regulation of antigen receptor-mediated signaling pathway|
|neuronal cell body membrane|
|negative regulation of calcium-mediated signaling|
|negative regulation of production of molecular mediator of immune response|
|regulation of B cell proliferation|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of immunoglobulin production|
|protein phosphatase binding|
|regulation of calcium-mediated signaling|
|recycling endosome|
|negative regulation of immune effector process|
|negative regulation of protein secretion|
|negative regulation of peptide secretion|
|regulation of production of molecular mediator of immune response|
|B cell activation|
|carbohydrate binding|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|regulation of endocytosis|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|negative regulation of secretion|
|early endosome|
|signaling receptor binding|
|lymphocyte activation|
|negative regulation of immune system process|
|regulation of protein secretion|
|regulation of immune effector process|
|negative regulation of transport|
|regulation of peptide secretion|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|regulation of vesicle-mediated transport|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|regulation of protein localization|
|cell activation|
|regulation of immune response|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD22 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>