CD40 [The Human Chemical-Genetic Interaction Map Project]

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======= CD40 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD40
  * **<color #00a2e8>Official Name</color>**: CD40 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=958|958]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25942|P25942]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD40&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD40|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of isotype switching to IgG isotypes|
|positive regulation of protein kinase C signaling|
|CD40 receptor complex|
|regulation of isotype switching to IgG isotypes|
|regulation of protein kinase C signaling|
|regulation of immunoglobulin secretion|
|positive regulation of endothelial cell apoptotic process|
|defense response to protozoan|
|response to protozoan|
|positive regulation of isotype switching|
|positive regulation of epithelial cell apoptotic process|
|regulation of isotype switching|
|positive regulation of interleukin-12 production|
|positive regulation of B cell mediated immunity|
|positive regulation of immunoglobulin mediated immune response|
|protein kinase B signaling|
|positive regulation of DNA recombination|
|B cell proliferation|
|positive regulation of B cell proliferation|
|positive regulation of immunoglobulin production|
|regulation of endothelial cell apoptotic process|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|regulation of interleukin-12 production|
|positive regulation of blood vessel endothelial cell migration|
|regulation of B cell proliferation|
|regulation of immunoglobulin production|
|positive regulation of tyrosine phosphorylation of STAT protein|
|cellular response to mechanical stimulus|
|regulation of epithelial cell apoptotic process|
|regulation of tyrosine phosphorylation of STAT protein|
|lymphocyte proliferation|
|positive regulation of receptor signaling pathway via JAK-STAT|
|mononuclear cell proliferation|
|positive regulation of receptor signaling pathway via STAT|
|regulation of blood vessel endothelial cell migration|
|positive regulation of production of molecular mediator of immune response|
|leukocyte proliferation|
|positive regulation of endothelial cell migration|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of DNA recombination|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|tumor necrosis factor-mediated signaling pathway|
|regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|positive regulation of leukocyte proliferation|
|platelet activation|
|regulation of production of molecular mediator of immune response|
|positive regulation of epithelial cell migration|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|positive regulation of NF-kappaB transcription factor activity|
|B cell activation|
|regulation of endothelial cell migration|
|regulation of adaptive immune response|
|positive regulation of angiogenesis|
|positive regulation of B cell activation|
|positive regulation of vasculature development|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidyl-tyrosine phosphorylation|
|defense response to virus|
|positive regulation of DNA metabolic process|
|signaling receptor activity|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|response to mechanical stimulus|
|positive regulation of immune effector process|
|regulation of epithelial cell migration|
|regulation of leukocyte proliferation|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|cellular response to tumor necrosis factor|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|response to virus|
|regulation of angiogenesis|
|blood coagulation|
|ubiquitin protein ligase binding|
|coagulation|
|hemostasis|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of vasculature development|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|enzyme binding|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|external side of plasma membrane|
|positive regulation of leukocyte activation|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|regulation of DNA-binding transcription factor activity|
|cellular calcium ion homeostasis|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of immune effector process|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cell population proliferation|
|cellular metal ion homeostasis|
|response to wounding|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|defense response to other organism|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8093
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD40 Expression in NALM6 Cells: 0.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>