CD6 [The Human Chemical-Genetic Interaction Map Project]

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======= CD6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD6
  * **<color #00a2e8>Official Name</color>**: CD6 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=923|923]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30203|P30203]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/186720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777). {ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:17601777, ECO:0000269|PubMed:24584089, ECO:0000269|PubMed:24945728}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRCR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipoteichoic acid binding|
|acute inflammatory response to antigenic stimulus|
|immunological synapse formation|
|positive regulation of cytokine production involved in inflammatory response|
|inflammatory response to antigenic stimulus|
|lipopolysaccharide-mediated signaling pathway|
|lipopolysaccharide binding|
|immunological synapse|
|intrinsic component of plasma membrane|
|regulation of cytokine production involved in inflammatory response|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|scavenger receptor activity|
|acute inflammatory response|
|cell-cell recognition|
|positive regulation of T cell proliferation|
|T cell receptor complex|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|positive regulation of inflammatory response|
|regulation of T cell proliferation|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|cell recognition|
|positive regulation of cell-cell adhesion|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|positive regulation of lymphocyte activation|
|lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|positive regulation of defense response|
|inflammatory response|
|cell-cell adhesion|
|regulation of lymphocyte activation|
|cellular response to lipid|
|endocytosis|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|adaptive immune response|
|regulation of cell activation|
|import into cell|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|response to lipid|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cellular response to oxygen-containing compound|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.71|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.72|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.85|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.86|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.97|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.436|
|[[:human genes:p:prim1|PRIM1]]|0.428|
|[[:human genes:p:plrg1|PLRG1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2926
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD6 Expression in NALM6 Cells: 1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>