CD80 [The Human Chemical-Genetic Interaction Map Project]

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======= CD80 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CD80
  * **<color #00a2e8>Official Name</color>**: CD80 molecule
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=941|941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33681|P33681]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CD80&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CD80|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/112203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269|PubMed:10583602}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2-set 2|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|
|protein complex involved in cell adhesion|
|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|
|positive regulation of T-helper 1 cell differentiation|
|regulation of T-helper 1 cell differentiation|
|positive regulation of granulocyte macrophage colony-stimulating factor production|
|positive regulation of interleukin-2 biosynthetic process|
|regulation of granulocyte macrophage colony-stimulating factor production|
|regulation of interleukin-2 biosynthetic process|
|positive regulation of T-helper 1 type immune response|
|positive regulation of T-helper cell differentiation|
|regulation of T-helper 1 type immune response|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of interleukin-2 production|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|coreceptor activity|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|T cell costimulation|
|regulation of interleukin-2 production|
|lymphocyte costimulation|
|regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of alpha-beta T cell activation|
|negative regulation of T cell proliferation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of cytokine biosynthetic process|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|virus receptor activity|
|negative regulation of leukocyte proliferation|
|positive regulation of T cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|viral entry into host cell|
|positive regulation of T cell proliferation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|entry into host|
|entry into host cell|
|regulation of cytokine biosynthetic process|
|positive regulation of adaptive immune response|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|regulation of T cell proliferation|
|interaction with host|
|regulation of adaptive immune response|
|positive regulation of protein kinase B signaling|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|cellular response to lipopolysaccharide|
|positive regulation of hemopoiesis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|negative regulation of cell activation|
|viral life cycle|
|positive regulation of T cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cellular response to biotic stimulus|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|regulation of protein kinase B signaling|
|regulation of leukocyte proliferation|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|response to lipopolysaccharide|
|regulation of T cell activation|
|response to molecule of bacterial origin|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of immune effector process|
|regulation of lymphocyte activation|
|cellular response to lipid|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|response to lipid|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|positive regulation of cell differentiation|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13195
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CD80 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>